Palladium Catalyzed [3+2] Cycloaddition of Vinyl Aziridine and Indane-1,3-diones: Diastereo- and Enantioselective Access to Spiro-Pyrrolidines
01 Pubblicazione su rivista
Vetica F, Bailey S J, Kumar M, Mahajan S, von Essen C, Rissanen K, Enders D
ISSN: 0039-7881
A mild and efficient palladium catalyzed [3+2] cycloaddition of vinyl aziridines and indane-1,3-diones has been realized. The resulting spiropyrrolidines were provided in excellent yields and, with the introduction of the leucine-derived phosphine ligand, moderate to good enantio- and diastereoselectivities.