Two-Step Synthesis of alpha,beta-Unsaturated gamma-Amino Acid Esters via N-Heterocyclic Carbene Catalyzed [4+2] Cycloaddition of Enals and Nitroso Compounds
01 Pubblicazione su rivista
Liu Q, Chen Xy, Li S, Vetica F, Raabe G, Enders D
ISSN: 0039-7881
An efficient strategy for the synthesis of various of ,-unsaturated -amino acid esters has been established employing N-heterocyclic carbene catalyzed [4+2] cycloadditions of -methyl enals and aromatic nitroso compounds to afford 1,2-oxazin-6-ones in good yields. A subsequent acid-catalyzed esterification under ring opening yields the -amino enoates in good yields.