Harmful effects of mechanical ventilation on neurocognitive functions
01 Pubblicazione su rivista
Bilotta F., Giordano G., Sergi P. G., Pugliese F.
ISSN: 1466-609X
Whether mechanical ventilation (MV) induces neurotoxicity that can trigger or accelerate chronic cognitive disorders is controversial [1, 2]. The relationship between MV and neurocognitive impairment—that persisted at hospital discharge and at 1-year follow up—was first reported in
1999 in MV-treated ARDS patients [3]. Since then, several preclinical and clinical studies have investigated the mechanisms, localization, and timing of brain damage induced by MVand possible preventive/therapeutic strategies.