Breast cancer subtypes affect the nodal response after neoadjuvant chemotherapy in locally advanced breast cancer: Are we ready to endorse axillary conservation?
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Cerbelli Bruna, Botticelli Andrea, Pisano Annalinda, Campagna Domenico, De Vincentiis Ludovica, Pernazza Angelina, Frusone Federico, Scavina Paola, Monti Massimo, Fortunato Lucio, Costarelli Leopoldo, D’Amati Giulia
DOI: 10.1111/tbj.13206
ISSN: 1075-122X
We evaluated the impact of breast cancer subtypes on pathologic complete response (pCR) in 181 patients with positive nodes undergoing neoadjuvant chemotherapy (NAC). After NAC, patients underwent surgery, with sentinel lymph node biopsy (SLNB) or axillary dissection (ALND). In 28.2% of cases a pCR was achieved, with the highest rate in Her2+ and triple negative tumors. Overall, nodal pCR was more frequent than breast pCR (P = 0.003) with higher percentages in Her2+ and LLB-Her2+ (P