Inhibition of Stearoyl-CoA desaturase 1 reverts BRAF and MEK inhibition-induced selection of cancer stem cells in BRAF-mutated melanoma
01 Pubblicazione su rivista
Pisanu Maria Elena, Maugeri-Saccà Marcello, Fattore Luigi, Bruschini Sara, De Vitis Claudia, Tabbì Eugenio, Bellei Barbara, Migliano Emilia, Kovacs Daniela, Camera Emanuela, Picardo Mauro, Jakopin Ziga, Cippitelli Claudia, Bartolazzi Armando, Raffa Salvatore, Torrisi Maria Rosaria, Fulciniti Franco, Ascierto Paolo A, Ciliberto Gennaro, Mancini Rita
ISSN: 1756-9966
Combination therapy with BRAF and MEK inhibitors significantly improves survival in BRAF mutated melanoma patients but is unable to prevent disease recurrence due to the emergence of drug resistance. Cancer stem cells (CSCs) have been involved in these long-term treatment failures. We previously reported in lung cancer that CSCs maintenance is due to altered lipid metabolism and dependent upon Stearoyl-CoA-desaturase (SCD1)-mediated upregulation of YAP and TAZ. On this ground, we investigated the role of SCD1 in melanoma CSCs.