Ricerc@Sapienza

Background. Wound healing is a dynamic process that depends not only on the interaction between different
cellular factors involved in the tissue repair process but can also be adjuvant by a daily nutritional support. Therefore
it can be considered a kind of specialized nutrition of which several elements favour the repair and wound healing
process. Objective: The aim of this study was to verify the effect of beta-hydroxy-beta-methylbutyrate (HMB). To investigate
the effects of the combination of arginine, beta-hydroxy-beta-methylbutyrate and glutamine in order to favour
collagen deposition on the wound bed. Materials and Methods: The research was conducted by analysing publications
of recent years and also by setting “title and abstract” as a search criterion. Results: From the studies conducted, it was
shown that by analysing the combined action of the amino acid mixture in relation to collagen deposition in humans,
in just two weeks the integration with arginine, HMB and glutamine produced a significant increase in plasma levels
of arginine and ornithine equal to 67%. Conclusions: HMB increases lean mass, improves muscle strength and exerts
anti-catabolism. Glutamine is essential in the metabolism of lymphocytes, enterocytes and other cells with a rapid
turnover. Collagen synthesis and scar formation are necessary for complete resolution of a wound.