Functional Role of the Secretin/Secretin Receptor Signaling During Cholestatic Liver Injury
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Wu N., Baiocchi L., Zhou T., Kennedy L., Ceci L., Meng F., Sato K., Wu C., Ekser B., Kyritsi K., Kundu D., Chen L., Meadows V., Franchitto A., Alvaro D., Onori P., Gaudio E., Lenci I., Francis H., Glaser S., Alpini G.
DOI: 10.1002/hep.31484
ISSN: 0270-9139
Liver diseases are a major health concern and affect a large proportion of people worldwide. There are over 100 types of liver disorders, including cirrhosis, cholangiocarcinoma (CCA), hepatocellular carcinoma, and hepatitis. Despite the relevant number of people who are affected by liver diseases, and the increased awareness with regard to these disorders, the number of deaths corresponding to liver injury is expected to increase in the foreseeable future. One of the possible reasons for this is that a complete comprehension of the mechanisms of hepatic damage involving specific liver anatomical districts is lacking, and, as a consequence, current treatments available are suboptimal.
CCA cholangiocarcinoma CFTR Cystic Fibrosis Transmembrane Conductance Regulator dnTGF-βRII dominant-negative transforming growth factor β receptor II Mdr2 multidrug resistance 2 (Abcb4) miRNA microRNA NGF nerve growth factor PBC primary biliary cholangitis PKA protein kinase A PSC primary sclerosing cholangitis Sct secretin