Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas
01 Pubblicazione su rivista
Schaub Franz X., Dhankani Varsha, Berger Ashton C., Trivedi Mihir, Richardson Anne B., Shaw Reid, Zhao Wei, Zhang Xiaoyang, Ventura Andrea, Liu Yuexin, Ayer Donald E., Hurlin Peter J., Cherniack Andrew D., Eisenman Robert N., Bernard Brady, Grandori Carla, Caesar-Johnson Samantha J., Demchok John A., Felau Ina, Kasapi Melpomeni, Ferguson Martin L., Hutter Carolyn M., Sofia Heidi J., Tarnuzzer Roy, Wang Zhining, Yang Liming, Zenklusen Jean C., Zhang Jiashan (Julia), Chudamani Sudha, Liu Jia, Lolla Laxmi, Naresh Rashi, Pihl Todd, Sun Qiang, Wan Yunhu, Wu Ye, Cho Juok, Defreitas Timothy, Frazer Scott, Gehlenborg Nils, Getz Gad, Heiman David I., Kim Jaegil, Lawrence Michael S., Lin Pei, Meier Sam, Noble Michael S., Saksena Gordon, Voet Doug, Zhang Hailei, Bernard Brady, Chambwe Nyasha, Dhankani Varsha, Knijnenburg Theo, Kramer Roger, Leinonen Kalle, Liu Yuexin, Miller Michael, Reynolds Sheila, Shmulevich Ilya, Thorsson Vesteinn, Zhang Wei, Akbani Rehan, Broom Bradley M., Hegde Apurva M., Ju Zhenlin, Kanchi Rupa S., Korkut Anil, Li Jun, Liang Han, Ling Shiyun, Liu Wenbin, Lu Yiling, Mills Gordon B., Ng Kwok-Shing, Rao Arvind, Ryan Michael, Wang Jing, Weinstein John N., Zhang Jiexin, Abeshouse Adam, Armenia Joshua, Chakravarty Debyani, Chatila Walid K., de Bruijn Ino, Gao Jianjiong, Gross Benjamin E., Heins Zachary J., Kundra Ritika, La Konnor, Ladanyi Marc, Luna Augustin, Nissan Moriah G., Ochoa Angelica, Phillips Sarah M., Reznik Ed, Sanchez-Vega Francisco, Sander Chris, Schultz Nikolaus, Sheridan Robert, Sumer S. Onur, Sun Yichao, Taylor Barry S., Wang Jioajiao, Zhang Hongxin, Anur Pavana, Peto Myron, Spellman Paul, Benz Christopher, Stuart Joshua M., Wong Christopher K., Yau Christina, Hayes D. Neil, Parker Joel S., Wilkerson Matthew D., Ally Adrian, Balasundaram Miruna, Bowlby Reanne, Brooks Denise, Carlsen Rebecca, Chuah Eric, Dhalla Noreen, Holt Robert, Jones Steven J. M., Kasaian Katayoon, Lee Darlene, Ma Yussanne, Marra Marco A., Mayo Michael, Moore Richard A., Mungall Andrew J., Mungall Karen, Robertson A. Gordon, Sadeghi Sara, Schein Jacqueline E., Sipahimalani Payal, Tam Angela, Thiessen Nina, Tse Kane, Wong Tina, Berger Ashton C., Beroukhim Rameen, Cherniack Andrew D., Cibulskis Carrie, Gabriel Stacey B., Gao Galen F., Ha Gavin, Meyerson Matthew, Schumacher Steven E., Shih Juliann, Kucherlapati Melanie H., Kucherlapati Raju S., Baylin Stephen, Cope Leslie, Danilova Ludmila, Bootwalla Moiz S., Lai Phillip H., Maglinte Dennis T., Van Den Berg David J., Weisenberger Daniel J., Auman J. Todd, Balu Saianand, Bodenheimer Tom, Fan Cheng, Hoadley Katherine A., Hoyle Alan P., Jefferys Stuart R., Jones Corbin D., Meng Shaowu, Mieczkowski Piotr A., Mose Lisle E., Perou Amy H., Perou Charles M., Roach Jeffrey, Shi Yan, Simons Janae V., Skelly Tara, Soloway Matthew G., Tan Donghui, Veluvolu Umadevi, Fan Huihui, Hinoue Toshinori, Laird Peter W., Shen Hui, Zhou Wanding, Bellair Michelle, Chang Kyle, Covington Kyle, Creighton Chad J., Dinh Huyen, Doddapaneni Harshavardhan, Donehower Lawrence A., Drummond Jennifer, Gibbs Richard A., Glenn Robert, Hale Walker, Han Yi, Hu Jianhong, Korchina Viktoriya, Lee Sandra, Lewis Lora, Li Wei, Liu Xiuping, Morgan Margaret, Morton Donna, Muzny Donna, Santibanez Jireh, Sheth Margi, Shinbrot Eve, Wang Linghua, Wang Min, Wheeler David A., Xi Liu, Zhao Fengmei, Hess Julian, Appelbaum Elizabeth L., Bailey Matthew, Cordes Matthew G., Ding Li, Fronick Catrina C., Fulton Lucinda A., Fulton Robert S., Kandoth Cyriac, Mardis Elaine R., Mclellan Michael D., Miller Christopher A., Schmidt Heather K., Wilson Richard K., Crain Daniel, Curley Erin, Gardner Johanna, Lau Kevin, Mallery David, Morris Scott, Paulauskis Joseph, Penny Robert, Shelton Candace, Shelton Troy, Sherman Mark
ISSN: 2405-4712
Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN.