Doets Alex Y., Verboon Christine, Van Den Berg Bianca, Harbo Thomas, Cornblath David R., Willison Hugh J., Islam Zhahirul, Attarian Shahram, Barroso Fabio A., Bateman Kathleen, Benedetti Luana, Van Den Bergh Peter, Casasnovas Carlos, Cavaletti Guido, Chavada Govindsinh, Claeys Kristl G., Dardiotis Efthimios, Davidson Amy, Van Doorn Pieter A., Feasby Tom E., Galassi Giuliana, Gorson Kenneth C., Hartung Hans-Peter, Hsieh Sung-Tsang, Hughes Richard A. C., Illa Isabel, Islam Badrul, Kusunoki Susumu, Kuwabara Satoshi, Lehmann Helmar C., Miller James A. L., Mohammad Quazi Deen, Monges Soledad, Nobile Orazio Eduardo, Pardo Julio, Pereon Yann, Rinaldi Simon, Querol Luis, Reddel Stephen W., Reisin Ricardo C., Shahrizaila Nortina, Sindrup Soren H., Waqar Waheed, Jacobs Bart C., Jacobs Bc, Hughes Rac, Cornblath Dr, Gorson Kc, Hartung Hp, Kusunoki S, van Doorn Pa, Willison Hj, van Woerkom M, van den Berg B, Verboon C, Doets Ay, Roodbol J, Jacobs Bc, Reisin Rc, Reddel Sw, Islam Z, Islam B, Mohammad Qd, van den Bergh P, Feasby Te, Harbo T, Péréon Y, Hartung Hp, Lehmann Hc, Dardiotis E, Nobile-Orazio E, Kusunoki S, Shahrizaila N, Jacobs Bc, van den Berg B, Verboon C, Doets Ay, Bateman K, Illa I, Querol L, Hsieh St, Willison Hj, Chavada G, Davidson A, Gorson Kc, Addington Jm, Ajroud-Driss S, Andersen H,
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Guillain-Barré syndrome is a heterogeneous disorder regarding the clinical presentation, electrophysiological subtype and outcome. Previous single country reports indicate that Guillain-Barré syndrome may differ among regions, but no systematic comparative studies have been conducted. Comparative studies are required to identify factors determining disease susceptibility, variation and prognosis, and to improve diagnostic criteria. The International Guillain-Barré Syndrome Outcome Study is a prospective, observational cohort study including all patients within the diagnostic spectrum, aiming to describe the heterogeneity of Guillain-Barré syndrome worldwide. The current study was based on the first 1000 inclusions with a follow-up of at least 1 year and confirmed the variation in clinical presentation, course and outcome between patients. The full clinical spectrum of Guillain-Barré syndrome was observed in patients from all countries participating in the International Guillain-Barré Syndrome Outcome Study, but the frequency of variants differed between regions. We compared three regions based on geography, income and previous reports of Guillain-Barré syndrome subtypes: Europe/Americas', Asia' (without Bangladesh), and Bangladesh'. We excluded 75 (8%) patients because of alternative diagnoses, protocol violations, or missing data. The predominant clinical variant was sensorimotor in Europe/Americas (n = 387/562, 69%) and Asia (n = 27/63, 43%), and pure motor in Bangladesh (n = 74/107, 69%). Miller Fisher syndrome and Miller Fisher-Guillain-Barré overlap syndrome were more common in Asia (n = 14/63, 22%) than in the other two regions (Europe/Americas: n = 64/562, 11%; Bangladesh: n = 1/107, 1%) (P