Disruption of MEK/ERK/c-Myc signaling radiosensitizes prostate cancer cells in vitro and in vivo
01 Pubblicazione su rivista
Ciccarelli Carmela, Di Rocco Agnese, Gravina Giovanni Luca, Mauro Annunziata, Festuccia Claudio, Del Fattore Andrea, Berardinelli Paolo, De Felice Francesca, Musio Daniela, Bouché Marina, Tombolini Vincenzo, Zani Bianca Maria, Marampon Francesco
ISSN: 0171-5216
Prostate cancer (PCa) cell radioresistance causes the failure of radiation therapy (RT) in localized or locally advanced disease. The aberrant accumulation of c-Myc oncoprotein, known to promote PCa onset and progression, may be due to the control of gene transcription and/or MEK/ERK-regulated protein stabilization. Here, we investigated the role of MEK/ERK signaling in PCa.