Analytical validation of a novel targeted next-generation sequencing assay for mutation detection in thyroid nodule aspirates and tissue
01 Pubblicazione su rivista
Verrienti Antonella, Pecce Valeria, Abballe Luana, Ramundo Valeria, Falcone Rosa, Inanloo Nigi Jak Farzaneh, Brunelli Chiara, Fadda Guido, Bosco Daniela, Ascoli Valeria, Carletti Raffaella, Di Gioia Cira, Grani Giorgio, Sponziello Marialuisa
ISSN: 1355-008X
The identification of somatic mutations in cancer specimens enables detection of molecular markers for personalized treatment. We recently developed a novel molecular assay and evaluated its clinical performance as an ancillary molecular method for indeterminate thyroid nodule cytology. Herein we describe the analytical validation of the novel targeted next-generation sequencing (NGS) assay in thyroid samples from different sources.