Cerebrospinal fluid HIV-1 escape according to different thresholds and underlying comorbidities. Is it time to assess the definitions?
01 Pubblicazione su rivista
Trunfio Mattia, Pinnetti Carmela, Focà Emanuele, Bai Francesca, Maffongelli Gaetano, Celani Luigi, Cinque Paola, Celotti Anna, Andreoni Massimo, D'Arminio Monforte Antonella, D'Ettorre Gabriella, Antinori Andrea, Calcagno Andrea
ISSN: 1473-5571
No consensus has been reached on how to define cerebrospinal fluid HIV-1 escape (CSF-E). We describe its prevalence in 1095 paired CSF-plasma HIV-RNA measurements from antiretroviral-treated patients according to several definitions and neurological affections. CSF-E prevalence varied substantially (9.0-38.9%) and was higher in patients with cerebrovascular disorders, HIV-associated dementia and white matter abnormalities. Considering the variability in HIV-RNA quantification assays, the biological relevance of viral escape at different thresholds needs to be accurately assessed.