Risultati ricerca pubblicazioni

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Berardozzi Simone, Bernardi Flavia, Infante Paola, Ingallina Cinzia, Toscano Sara, De Paolis Elisa, Alfonsi Romina, Caimano Miriam, Botta Bruno, Mori Mattia, Di Marcotullio Lucia, Ghirga Francesca

Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Carradori Simone, Ottuso Francesco, Petzer Anèl, Bagetta Donatella, DE MONTE Celeste, Secci Daniela, DE VITA Daniela, Guglielmi Paolo, Zengin Gokhan, Aktumsek Abdurrahman, Alcaro Stefano, Petzer Jacobus P.

Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Saccoliti Francesco, Madia VALENTINA NOEMI, Tudino Valeria, DE LEO Alessandro, Pescatori Luca, Messore Antonella, DE VITA Daniela, Scipione Luigi, Brun Reto, Kaiser Marcel, Mäser Pascal, Magalhaes Calvet Claudia, K Jennings Gareth, M Podust Larissa, Costi Roberta, DI SANTO Roberto

In vivo potent BM635 analogue with improved drug-like properties

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Poce Giovanna, Cocozza Martina, Alfonso Salvatore, Consalvi Sara, Venditti Giulia, Fernandez-Menendez Raquel, Bates Robert H., Barros Aguirre David, Ballell Lluis, De Logu Alessandro, Vistoli Giulio, Biava Mariangela

Naturally occurring diels-alder-type adducts from morus nigra as potent inhibitors of mycobacterium tuberculosis protein tyrosine phosphatase B

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Mascarello Alessandra, Orbem Menegatti Angela Camila, Calcaterra Andrea, Martins Priscila Graziela Alves, Chiaradia-Delatorre Louise Domeneghini, D'Acquarica Ilaria, Ferrari Franco, Pau Valentina, Sanna Adriana, De Logu Alessandro, Botta Maurizio, Botta Bruno, Terenzi Hernã¡n, Mori Mattia

New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

La Regina Giuseppe, Bai Ruoli, Coluccia Antonio, Naccarato Valentina, Famiglini Valeria, Nalli Marianna, Masci Domiziana, Verrico Annalisa, Rovella Paola, Mazzoccoli Carmela, Da Pozzo Eleonora, Cavallini Chiara, Martini Claudia, Vultaggio Stefania, Dondio Giulio, Varasi Mario, Mercurio Ciro, Hamel Ernest, Lavia Patrizia, Silvestri Romano

Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Talapatra Sandeep K., Tham Chuin Lean, Guglielmi Paolo, Cirilli Roberto, Chandrasekaran Balakumar, Karpoormath Rajshekhar, Carradori Simone, Kozielski Frank

Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for α4β2nACh receptors

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Deligia Francesco, Murineddu Gabriele, Gotti Cecilia, Ragusa Giulio, Fasoli Francesca, Sciaccaluga Miriam, Plutino Simona, Fucile Sergio, Loriga Giovanni, Asproni Battistina, Pinna Gerard A

Efficient synthesis and first regioselective C-6 direct arylation of imidazo[2,1-c][1,2,4]triazine scaffold and their evaluation in H2O2-induced oxidative stress

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Loubidi Mohammed, Jouha Jabrane, Tber Zahira, Khouili Mostafa, Suzenet Franck, Akssira Mohamed, Erdogan Mümin Alper, Köse Fadime Aydın, Dagcı Taner, Armagan Güliz, Saso Luciano, Guillaumet Gérald