Risultati ricerca pubblicazioni

Discovery of phenylselenoether-hydantoin hybrids as ABCB1 efflux pump modulating agents with cytotoxic and antiproliferative actions in resistant T-lymphoma

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2020

Ali Wesam, Spengler Gabriella, Kincses Annamária, Nové Márta, Battistelli Cecilia, Latacz Gniewomir, Starek Małgorzata, Dąbrowska Monika, Honkisz-Orzechowska Ewelina, Romanelli Annalisa, Rasile Manuela Monica, Szymańska Ewa, Jacob Claus, Zwergel Clemens, Handzlik Jadwiga

Development of alkyl glycerone phosphate synthase inhibitors: Structure-activity relationship and effects on ether lipids and epithelial-mesenchymal transition in cancer cells

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2019

Stazi Giulia, Battistelli Cecilia, Piano Valentina, Mazzone Roberta, Marrocco Biagina, Marchese Sara, Louie Sharon M., Zwergel Clemens, Antonini Lorenzo, Patsilinakos Alexandros, Ragno Rino, Viviano Monica, Sbardella Gianluca, Ciogli Alessia, Fabrizi Giancarlo, Cirilli Roberto, Strippoli Raffaele, Marchetti Alessandra, Tripodi Marco, Nomura Daniel K., Mattevi Andrea, Mai Antonello, Valente Sergio

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Berardozzi Simone, Bernardi Flavia, Infante Paola, Ingallina Cinzia, Toscano Sara, De Paolis Elisa, Alfonsi Romina, Caimano Miriam, Botta Bruno, Mori Mattia, Di Marcotullio Lucia, Ghirga Francesca

New deferiprone derivatives as multi-functional cholinesterase inhibitors. Design, synthesis and in vitro evaluation

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2020

Bortolami Martina, Pandolfi Fabiana, De Vita Daniela., Carafa Camilla, Messore Antonella, DI SANTO Roberto, Feroci Marta, Costi Roberta, Chiarotto Isabella, Bagetta Donatella, Alcaro Stefano, Colone Marisa, Stringaro Annarita, Scipione Luigi

Searching for new agents active against candida albicans biofilm: a series of indole derivatives, design, synthesis and biological evaluation

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2019

Pandolfi Fabiana, D'Acierno Federica, Bortolami Martina, De Vita Daniela, Gallo Fabio, De Meo Alessandra, Di Santo Roberto, Costi Roberta, Simonetti Giovanna, Scipione Luigi

Design, synthesis and biochemical evaluation of novel multi-target inhibitors as potential anti-Parkinson agents

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Carradori Simone, Ottuso Francesco, Petzer Anèl, Bagetta Donatella, DE MONTE Celeste, Secci Daniela, DE VITA Daniela, Guglielmi Paolo, Zengin Gokhan, Aktumsek Abdurrahman, Alcaro Stefano, Petzer Jacobus P.

Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Saccoliti Francesco, Madia VALENTINA NOEMI, Tudino Valeria, DE LEO Alessandro, Pescatori Luca, Messore Antonella, DE VITA Daniela, Scipione Luigi, Brun Reto, Kaiser Marcel, Mäser Pascal, Magalhaes Calvet Claudia, K Jennings Gareth, M Podust Larissa, Costi Roberta, DI SANTO Roberto

In vivo potent BM635 analogue with improved drug-like properties

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Poce Giovanna, Cocozza Martina, Alfonso Salvatore, Consalvi Sara, Venditti Giulia, Fernandez-Menendez Raquel, Bates Robert H., Barros Aguirre David, Ballell Lluis, De Logu Alessandro, Vistoli Giulio, Biava Mariangela

Naturally occurring diels-alder-type adducts from morus nigra as potent inhibitors of mycobacterium tuberculosis protein tyrosine phosphatase B

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Mascarello Alessandra, Orbem Menegatti Angela Camila, Calcaterra Andrea, Martins Priscila Graziela Alves, Chiaradia-Delatorre Louise Domeneghini, D'Acquarica Ilaria, Ferrari Franco, Pau Valentina, Sanna Adriana, De Logu Alessandro, Botta Maurizio, Botta Bruno, Terenzi Hernã¡n, Mori Mattia

Structure-activity relationship studies and in vitro and in vivo anticancer activity of novel 3-aroyl-1,4-diarylpyrroles against solid tumors and hematological malignancies

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2020

Puxeddu M., Shen H., Bai R., Coluccia A., Nalli M., Mazzoccoli C., Da Pozzo E., Cavallini C., Martini C., Orlando V., Biagioni S., Mazzoni C., Coluccia A. M. L., Hamel E., Liu T., Silvestri R., La Regina G.

New indolylarylsulfone non-nucleoside reverse transcriptase inhibitors show low nanomolar inhibition of single and double HIV-1 mutant strains

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2020

Nalli M., Armijos Rivera J. I., Masci D., Coluccia A., Badia R., Riveira-Muñoz E., Brambilla A., Cinquina E., Turriziani O., Falasca F., Catalano M., Limatola C., Esté J. A., Maga G., Silvestri R., Crespan E., La Regina G.

Switching on the activity of 1,5-diaryl-pyrrole derivatives against drug-resistant ESKAPE bacteria: structure-activity relationships and mode of action studies

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2019

Masci D., Hind C., Islam M. K., Toscani A., Clifford M., Coluccia A., Conforti Irene, Touitou M., Memdouh S., Wei X., La Regina G., Silvestri R., Sutton J. M., Castagnolo D.

New 6- and 7-heterocyclyl-1H-indole derivatives as potent tubulin assembly and cancer cell growth inhibitors

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

La Regina Giuseppe, Bai Ruoli, Coluccia Antonio, Naccarato Valentina, Famiglini Valeria, Nalli Marianna, Masci Domiziana, Verrico Annalisa, Rovella Paola, Mazzoccoli Carmela, Da Pozzo Eleonora, Cavallini Chiara, Martini Claudia, Vultaggio Stefania, Dondio Giulio, Varasi Mario, Mercurio Ciro, Hamel Ernest, Lavia Patrizia, Silvestri Romano

Identification of novel quinazoline derivatives as potent antiplasmodial agents

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2019

Bouchut A, Rotili D, Pierrot C, Valente S, Lafitte S, Schultz J, Hoglund U, Mazzone R, Lucidi A, Fabrizi G, Pechalrieu D, Arimondo Pb, Skinner-Adams Ts, Chua Mj, Andrews Kt, Mai A, Khalife J.

Chalcones: Unearthing their therapeutic possibility as monoamine oxidase B inhibitors

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2020

Guglielmi Paolo, Mathew Bijo, Secci Daniela, Carradori Simone

Crystal structure of the Eg5 - K858 complex and implications for structure-based design of thiadiazole-containing inhibitors

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Talapatra Sandeep K., Tham Chuin Lean, Guglielmi Paolo, Cirilli Roberto, Chandrasekaran Balakumar, Karpoormath Rajshekhar, Carradori Simone, Kozielski Frank

Novel coumarin- and quinolinone-based polycycles as cell division cycle 25-A and -C phosphatases inhibitors induce proliferation arrest and apoptosis in cancer cells

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2017

Zwergel Clemens, Czepukojc Brigitte, Evain Bana Emilie, Xu Zhanjie, Stazi Giulia, Mori Mattia, Patsilinakos Alexandros, Mai Antonello, Botta Bruno, Ragno Rino, Bagrel Denise, Kirsch Gilbert, Meiser Peter, Jacob Claus, Montenarh Mathias, Valente Sergio

New pyridine derivatives as inhibitors of acetylcholinesterase and amyloid aggregation

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2017

Pandolfi Fabiana, DE VITA Daniela, Bortolami Martina, Coluccia Antonio, DI SANTO Roberto, Costi Roberta, Andrisano Vincenza, Alabiso Francesco, Bergamini Christian, Fato Romana, Bartolini Manuela, Scipione Luigi

Heterocyclic pharmacochemistry of new rhinovirus antiviral agents: a combined computational and experimental study

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2017

Da Costa Laurene, Scheers Els, Coluccia Antonio, Rosetti Alessia, Roche Manon, Neyts Johan, Terme Thierry, Cirilli Roberto, Mirabelli Carmen, Silvestri Romano, Vanelle Patrice

Inhibitors of yellow fever virus replication based on 1,3,5-triphenyl-4,5-dihydropyrazole scaffold: design, synthesis and antiviral evaluation

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2017

Fioravanti Rossella, Desideri Nicoletta, Carta Antonio, Atzori Elena Maria, Delogu Ilenia, Collu Gabriella, Loddo Roberta

Novel N-aryl nicotinamide derivatives: Taking stock on 3,6-diazabicyclo[3.1.1]heptanes as ligands for neuronal acetylcholine receptors

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2019

Murineddu G, Gotti C, Asproni B, Corona P, Martinello K, Plutino S, Fucile S, Temml V, Moretti M, Viani P, Schuster D, Piras S, Deligia F, Pinna GA

Pyridinyl- and pyridazinyl-3,6-diazabicyclo[3.1.1]heptane-anilines: Novel selective ligands with subnanomolar affinity for α4β2nACh receptors

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Deligia Francesco, Murineddu Gabriele, Gotti Cecilia, Ragusa Giulio, Fasoli Francesca, Sciaccaluga Miriam, Plutino Simona, Fucile Sergio, Loriga Giovanni, Asproni Battistina, Pinna Gerard A

From pyrrolidinyl-benzodioxane to pyrrolidinyl-pyridodioxanes, or from unselective antagonism to selective partial agonism at ?4?2 nicotinic acetylcholine receptor

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2017

Bolchi Cristiano, Bavo Francesco, Gotti Cecilia, Fumagalli Laura, Fasoli Francesca, Binda Matteo, Mucchietto Vanessa, Sciaccaluga Miriam, Plutino Simona, Fucile Sergio, Pallavicini Marco

Efficient synthesis and first regioselective C-6 direct arylation of imidazo[2,1-c][1,2,4]triazine scaffold and their evaluation in H2O2-induced oxidative stress

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2018

Loubidi Mohammed, Jouha Jabrane, Tber Zahira, Khouili Mostafa, Suzenet Franck, Akssira Mohamed, Erdogan Mümin Alper, Köse Fadime Aydın, Dagcı Taner, Armagan Güliz, Saso Luciano, Guillaumet Gérald

Synthesis of new heterocyclic compounds based on pyrazolopyridine scaffold and evaluation of their neuroprotective potential in MPP+-induced neurodegeneration

pubblicato su: EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY - 2017

Jouha J., Loubidi M., Bouali J., Hamri S., Hafid A., Suzenet F., Guillaumet G., Dagc? T., Khouili M., Ayd?n F., Saso L., Armagan G.

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