Enrico De Smaele

Pubblicazioni

Titolo Pubblicato in Anno
Che-1/AATF binds to RNA polymerase I machinery and sustains ribosomal RNA gene transcription NUCLEIC ACIDS RESEARCH 2020
Hedgehog-GLI signalling promotes chemoresistance through the regulation of ABC transporters in colorectal cancer cells SCIENTIFIC REPORTS 2020
Downregulation of miR-326 and its host gene β-arrestin1 induces pro survival activity of E2F1 and promotes medulloblastoma growth MOLECULAR ONCOLOGY 2020
Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance CELLS 2020
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation CELL DEATH & DISEASE 2020
Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation INTERNATIONAL JOURNAL OF ONCOLOGY 2019
EZH2, JMJD3 and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells CELL DEATH & DISEASE 2019
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP NATURE COMMUNICATIONS 2019
KCTD15 inhibits the Hedgehog pathway in Medulloblastoma cells by increasing protein levels of the oncosuppressor KCASH2 ONCOGENESIS 2019
SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors SCIENTIFIC REPORTS 2019
The stem cell-associated transcription co-factor, ZNF521, interacts with GLI1 and GLI2 and enhances the activity of the Sonic hedgehog pathway CELL DEATH & DISEASE 2019
Foxm1 controls a pro-stemness microRNA network in neural stem cells SCIENTIFIC REPORTS 2018
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis NATURE COMMUNICATIONS 2018
Sonic hedgehog medulloblastoma cancer stem cells mirnome and transcriptome highlight novel functional networks INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2018
Numb Isoforms Deregulation in Medulloblastoma and Role of p66 Isoform in Cancer and Neural Stem Cells FRONTIERS IN PEDIATRICS 2018
STUDY OF THE TRANSCRIPTIONAL REGULATION OF THE ONCOSUPPRESSOR KCASH2 JOURNAL OF BIOLOGICAL REGULATORS & HOMEOSTATIC AGENTS 2018
Curcumin blocks autophagy and activates apoptosis of malignant mesothelioma cell lines and increases the survival of mice intraperitoneally transplanted with a malignant mesothelioma cell line ONCOTARGET 2017
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma. SCIENTIFIC REPORTS 2017
Noncanonical GLI1 signaling promotes stemness features and in vivo growth in lung adenocarcinoma ONCOGENE 2017
β-arrestin1-mediated acetylation of Gli1 regulates Hedgehog/Gli signaling and modulates self-renewal of SHH medulloblastoma cancer stem cells BMC CANCER 2017

ERC

  • LS2_3
  • LS3_1
  • LS3_5
  • LS4_12

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Principali interessi di ricerca.

- Biologia molecolare dei tumori

- medulloblastoma

- Hedgehog signalling in development and disease

- NFkB pathway and carcinogenesis

- miRNAs and cancer

KCTD proteins and cancer

Keywords

Sonic hedgehog pathway
NF-kappa B
Medulloblastoma
KCTD21
KCTD15
miRNA
cancer biology

Progetti di Ricerca

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma