Saggio has developed three major fields of research. The first deals with the relations between Information Technology and Architecture. The second concerns with the study of contemporary architecture particularly Italian Rationalism. The third deals with urban and architectural design. He studied and applied Low rise - High density housing solutions in the inner city, new strategies for new households and in the last years he developed complex urban projects that are based on a multitasking approach to create a new type of ecological infrastructures in the inner city. Three projects are under development in Rome: Urban Green Line, Tevere Cavo and UnLost Territories.
In the field of Information Technology, Saggio founded and edited the international book series "The Information Technology Revolution in Architecture” since 1998. The book series is very popular among students and scholars around the world. It has being being published in English (by Birkhäuser and Edilstampa 33 books), in Chinese (by Prominence, 9 books) and in Italian (Testo&Immagine, Edilstampa 38 books). The books represent an important theoretical and cultural survey of the new digital realm of architecture.
In the field of the study of contemporary architecture, Saggio published Giuseppe Terragni Life and Works (Laterza, 1995 2004, 2005, 2011), Architecture and Modernity. From Bauhaus to the IT Revolution (Carocci 2010), and books on Peter Eisenman, Frank Gehry, Giuseppe Pagano. In the field of urban and architectural design he published Louis Sauer, An American Architect (Officina 1988 and in English in 2012) and lately he curated a monographic issue of "L'Arca international” (March 2012) dedicated to the "Urban Green Line an Ecological infrastructure for Rome between Past and Future”
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