Giuseppe La Regina

Pubblicazioni

Titolo Pubblicato in Anno
New 1-phenyl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides inhibit hepatitis C virus replication via suppression of cyclooxygenase-2 EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 2015
Structure-based lead optimization and biological evaluation of BAX direct activators as novel potential anticancer agents JOURNAL OF MEDICINAL CHEMISTRY 2015
Pharmacological folding chaperones act as allosteric ligands of Frizzled4 NATURE CHEMICAL BIOLOGY 2015
Kinetic characterization of 4,4'-biphenylsulfonamides as selective non-zinc binding MMP inhibitors JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY 2015
Discovery of 1,1'-biiphenyl-4-sulfonamides as a new class of potent and selective carbonic anhydrase XIV inhibitors JOURNAL OF MEDICINAL CHEMISTRY 2015
Endogenous vs exogenous allosteric modulators in GPCRs: a dispute for shuttling CB1 among different membrane microenvironments SCIENTIFIC REPORTS 2015
New Indole Tubulin Assembly Inhibitors Cause Stable Arrest of Mitotic Progression, Enhanced Stimulation of Natural Killer Cell Cytotoxic Activity, and Repression of Hedgehog-Dependent Cancer JOURNAL OF MEDICINAL CHEMISTRY 2015
Poster: "In vivo selection of JARID histone demethylases inhibitors and their use to enlighten the biological role of these enzymes in yeast and mammalian cells with focus on transcriptional regulation” Abstracts of the 27th International Conference on Yeast Genetics and Molecular Biology 2015
New indole tubulin assembly inhibitors with stable arrest of mitotic progression, enhanced stimulation of natural killer cell cytotoxic activity and repression of Hedgehog-dependent cancer SIMCC2015 2015
Synthesis of New Indoles with Potent Tubulin Polymerization Inhibiting Activity Including Hedgehog-Dependent Cancer and Enhanced Stimulation of NK Cell Cytotoxic Activity Abstract eBook 2015
New Pyrazolecarboxamides a s Anti-HCV Agents via Targeting Cyclooxygenase-2 Abstract eBook 2015
Drug Design and Synthesis of New Indolylarylsulfones as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors Abstract eBook 2015

ERC

  • LS1_13
  • PE5_17
  • PE5_18

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Progettazione, sintesi e sviluppo di agenti anti-infettivi (HIV-1, Rhinovirus, virus dell’epatite C, virus Dengue, Mycobacterium tuberculosis, Candida albicans), anti-tumorali (tubulina, apoptosi, istone demetilasi, metalloproteinasi di matrice, membri della famiglia BCL-2, Frizzled4, anidrasi carbonica, indolamina 2,3-diossigenasi 1, MDM2/MDM4, NHERF1, beta-catenina) e attivi sul sistema nervoso centrale (monoammino ossidasi, sistema endocannabinoide, glicogeno sintasi chinasi 3 beta); sintesi microonde-assistita; studi di modellistica molecolare.

Keywords

drug design and discovery
Anti-Infective Agents
anticancer agent

Progetti di Ricerca

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