Giorgio Mangino

Pubblicazioni

Titolo Pubblicato in Anno
Multifunctional FFP2 face mask for white light disinfection and pathogens detection using hybrid nanostructures and optical metasurfaces SMALL 2024
In Vitro Evaluation of the Antioxidant Capacity of 3,3-Disubstituted-3H-benzofuran-2-one Derivatives in a Cellular Model of Neurodegeneration LIFE 2024
Extracellular vescicles in psoriasis. From pathogenesis to possible roles in therapy FRONTIERS IN IMMUNOLOGY 2024
CD20 + T lymphocytes in isolated Hashimoto's thyroiditis and type 3 autoimmune polyendocrine syndrome: a pilot study JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 2024
Dysregulated inflammatory cytokine levels may be useful markers in a better up-dated management of COVID 19 CURRENT ISSUES IN MOLECULAR BIOLOGY 2024
Memory T Cells Subpopulations in a Cohort of COVID-19 Vaccinated or Recovered Subjects VIRAL IMMUNOLOGY 2024
Inflammatory Response Modulation by Low-Dose Anti-inflammatory Drugs Treatment in an in vitro Osteoarthritis Cellular Model CURRENT MEDICINAL CHEMISTRY 2023
MicroRNAs Differentially Expressed in Actinic Keratosis and Healthy Skin Scrapings BIOMEDICINES 2023
The E6 and E7 proteins of beta3 human papillomavirus 49 can deregulate both cellular and extracellular vesicles-carried microRNAs INFECTIOUS AGENTS AND CANCER 2022
Human platelet lysate‐derived extracellular vesicles enhance angiogenesis through miR‐126 CELL PROLIFERATION 2022
Regulatory B Cells in Systemic Sclerosis Isolated or Concomitant With Hashimoto Thyroiditis FRONTIERS IN IMMUNOLOGY 2022
Polysialic acid sustains the hypoxia-induced migration and undifferentiated state of human glioblastoma cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Potential Pathogenetic Role of Antimicrobial Peptides Carried by Extracellular Vesicles in an in vitro Psoriatic Model JOURNAL OF INFLAMMATION RESEARCH 2022
Biomimetic keratin gold nanoparticle-mediated in vitro photothermal therapy on glioblastoma multiforme NANOMEDICINE 2021
Virus-induced tumorigenesis and ifn system BIOLOGY 2021
Human papillomavirus and carcinogenesis: novel mechanisms of cell communication involving extracellular vesicles CYTOKINE & GROWTH FACTOR REVIEWS 2020
Introduction to the special issue: extracellular vesicles and biological signal delivery in the inflammatory microenvironment CYTOKINE & GROWTH FACTOR REVIEWS 2020
BRAF Inhibitors. Molecular targeting and immunomodulatory actions CANCERS 2020
Role of CD 20+ T cells and related cytokines in mediating retinal microvascular changes and ocular complications in chronic-plaque type psoriasis CYTOKINE 2020
Mechanisms of acquired BRAF inhibitor resistance in melanoma. A systematic review CANCERS 2020

ERC

  • LS3_5
  • LS4_12
  • LS6

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Durante il mio percorso di ricerca mi sono occupato dei pathways di trasduzione del segnale degli Interferoni di tipo I e II, di quelli del recettore delle cellule T e della molecola ad attività co-stimolatoria CD28 con particolare riferimento alla funzione della proteina Vav e dell'influenza della proteina virale Nef, fattore di virulenza del virus dell’immunodeficienza acquisita umana (HIV), sulla trasduzione dei segnali nei macrofagi e nelle cellule microgliali.

Ad oggi, mi occupo principalmente dei meccanismi molecolari che sottendono alla trasformazione tumorale indotta dai Papillomavirus umani con particolare riferimento alla capacità di HPV di modulare il microambiente tumorale attraverso la deregolazione delle cito/-chemochine prodotte e del rilascio di vescicole extracellulari.

In qualità di Citometrista collaboro ai diversi progetti di ricerca sviluppati all’interno dei differenti laboratori afferenti al Dipartimento, ove richiesto l’utilizzo di tecniche di tipo citometrico.

Keywords

HPV
tumor microenvironment
exosomes and microvesicles
Signal Transduction
microRNA
acute and chronic inflammation diseases
Interferon

Laboratori di ricerca

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