Francesca Bufalieri | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
MYC upstream region orchestrates resistance to PI3K inhibitors in cancer cells through FOXO3a-mediated autophagic adaptation	ONCOGENE	2024
Combined inhibition of polyamine metabolism and eIF5A hypusination suppresses colorectal cancer growth through a converging effect on MYC translation	CANCER LETTERS	2023
SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma	CELL DEATH AND DIFFERENTIATION	2023
ERAP1 as an emerging therapeutic target for medulloblastoma	TRENDS IN CANCER	2022
Proteolysis-Targeting Chimera (PROTAC): Is the Technology Looking at the Treatment of Brain Tumors?	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY	2022
A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma	NEUROPATHOLOGY & APPLIED NEUROBIOLOGY	2022
Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma	CANCER LETTERS	2021
Harnessing the activation of RIG-I like receptors to inhibit glioblastoma tumorigenesis	FRONTIERS IN MOLECULAR NEUROSCIENCE	2021
The rna-binding ubiquitin ligase mex3a affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of rig-i	CANCERS	2020
The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma	EXPERT OPINION ON THERAPEUTIC TARGETS	2020
Dual smo/braf inhibition by flavonolignans from silybum marianum†	ANTIOXIDANTS	2020
Dubs activating the hedgehog signaling pathway: a promising therapeutic target in cancer	CANCERS	2020
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP	NATURE COMMUNICATIONS	2019
Targeting hedgehog signalling through the ubiquitylation process: the multiple roles of the HECT-E3 ligase itch	CELLS	2019
A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth	CANCERS	2019
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis	NATURE COMMUNICATIONS	2018
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.	SCIENTIFIC REPORTS	2017
Maml1 acts cooperatively with Gli proteins to regulate Sonic hedgheog signaling pathway	CELL DEATH & DISEASE	2017
Corrigendum: Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma	SCIENTIFIC REPORTS	2017

Progetti di Ricerca

Understanding the role of the E3 ubiquitin ligase TRIM21 in the Hedgehog pathway control and Hedgehog-dependent tumorigenesis.