Ludovica Lospinoso Severini

Pubblicazioni

Titolo	Pubblicato in	Anno
The RIG-I agonist M8 triggers cell death and natural killer cell activation in human papillomavirus-associated cancer and potentiates cisplatin cytotoxicity	CANCER IMMUNOLOGY, IMMUNOTHERAPY	2023
SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma	CELL DEATH AND DIFFERENTIATION	2023
Proteolysis-Targeting Chimera (PROTAC): Is the Technology Looking at the Treatment of Brain Tumors?	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY	2022
Glabrescione B delivery by self-assembling micelles efficiently inhibits tumor growth in preclinical models of Hedgehog-dependent medulloblastoma	CANCER LETTERS	2021
Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY	2021
SMA-miRs (MiR-181a- 5p, -324-5p, and -451a) are overexpressed in spinal muscular atrophy skeletal muscle and serum samples	ELIFE	2021
Drug delivery systems for hedgehog inhibitors in the treatment of SHH-medulloblastoma	FRONTIERS IN CHEMISTRY	2021
The SHH/GLI signaling pathway: a therapeutic target for medulloblastoma	EXPERT OPINION ON THERAPEUTIC TARGETS	2020
Dubs activating the hedgehog signaling pathway: a promising therapeutic target in cancer	CANCERS	2020
ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP	NATURE COMMUNICATIONS	2019
Targeting hedgehog signalling through the ubiquitylation process: the multiple roles of the HECT-E3 ligase itch	CELLS	2019
A Smo/Gli multitarget hedgehog pathway inhibitor impairs tumor growth	CANCERS	2019
Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2018
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis	NATURE COMMUNICATIONS	2018