Mara Cirone | Ricerc@Sapienza

Pubblicazioni

Titolo	Pubblicato in	Anno
Cancer Chemotherapy: Combination with Inhibitors (Volume I)	CANCERS	2024
NRF2 activation in BON‑1 neuroendocrine cancer cells reduces the cytotoxic effects of a novel Ruthenium(II)‑curcumin compound: A pilot study	ONCOLOGY REPORTS	2024
New insights into the Bortezomib‐induced cytotoxic and resistance mechanisms in a primary effusion lymphoma mouse model	HEMATOLOGICAL ONCOLOGY	2024
5-AZA Upregulates SOCS3 and PTPN6/SHP1, Inhibiting STAT3 and Potentiating the Effects of AG490 against Primary Effusion Lymphoma Cells	CURRENT ISSUES IN MOLECULAR BIOLOGY	2024
ATF6 supports lysosomal function in tumor cells to enable ER stress-activated macroautophagy and CMA: impact on mutant TP53 expression	AUTOPHAGY	2024
Recent Advances on Mutant p53: Unveiling Novel Oncogenic Roles, Degradation Pathways, and Therapeutic Interventions	BIOMOLECULES	2024
SAHA/5-AZA Enhances Acetylation and Degradation of mutp53, Upregulates p21 and Downregulates c-Myc and BRCA-1 in Pancreatic Cancer Cells	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2024
Post-translational modifications (PTMs) of mutp53 and epigenetic changes induced by mutp53	BIOLOGY	2024
EZH2 Inhibition by DS3201 triggers the kaposi’s sarcoma-associated herpesvirus lytic cycle and potentiates the effects induced by SAHA in primary effusion lymphoma cells	VIRUSES	2024
EBV infection alters DNA methylation in primary human colon cells: A path to inflammation and carcinogenesis?	BIOCHIMICA ET BIOPHYSICA ACTA. GENE REGULATORY MECHANISMS	2024
Different outcome of targeting ERN1/IRE1 alpha and EIF2AK3/PERK in NSG mice engrafted with primary effusion lymphoma	BRITISH JOURNAL OF HAEMATOLOGY	2023
The Sweet Side of HIPK2	CANCERS	2023
Antitumoral effects of Bortezomib in malignant mesothelioma: evidence of mild endoplasmic reticulum stress in vitro and activation of T cell response in vivo	BIOLOGY DIRECT	2023
HHV-6A Infection of Papillary Thyroid Cancer Cells Induces Several Effects Related to Cancer Progression	VIRUSES	2023
The inhibition of IRE1alpha/XBP1 axis prevents EBV-driven lymphomagenesis in NSG mice	MICROBIOLOGY SPECTRUM	2023
NRF2 and Bip Interconnection Mediates Resistance to the Organometallic Ruthenium-Cymene Bisdemethoxycurcumin Complex Cytotoxicity in Colon Cancer Cells	BIOMEDICINES	2023
HSP110 Inhibition in Primary Effusion Lymphoma Cells: One Molecule, Many Pro-Survival Targets	CANCERS	2023
NFE2L2 and STAT3 Converge on Common Targets to Promote Survival of Primary Lymphoma Cells	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2023
mTORC1/ERK1/2 Interplay Regulates Protein Synthesis and Survival in Acute Myeloid Leukemia Cell Lines	BIOLOGY	2023
HSPs/STAT3 Interplay Sustains DDR and Promotes Cytokine Release by Primary Effusion Lymphoma Cells	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2023

ERC

LS1_2
LS1_9
LS4_12
LS6
LS6_5

Interessi di ricerca

Oncoimmunologia Virale. Autofagia nella cancerogenesi virale e chimica. Target therapies e UPR e autophagy targeting nel cancro.

Keywords

Herpesvirus 4

BASI BIOLOGICHE DEL CANCRO

anti-tumor immune response

Herpesvirus 8

endoplasmic reticulum (ER stress)

Progetti di Ricerca

Exploitng the interplay between Unfolded Protein Response and DNA damage response to potentiate the efficacy of anticancer therapies
Manipulation of UPR and PRR signaling as strategy to reduce the side effects of herpesvirus-induced inflammation.
Coinvolgimento dell'autofagia nella trasformazione maligna mediata da EBV e KSHV.
Manipolazione dell'autofagia e dell'effetto Warbourg come strategia per modificare il cross-talk tra cellule tumorali KSHV-associate e microambiente tumorale
Manipulation of UPR in tumor cells and dendritic cells or macrophages exposed to tumor released factors to counteract tumor-induced immune dysfunction .

Laboratori di ricerca

Immuno-Oncologia Virale