Roberta Gonnella

Pubblicazioni

Titolo Pubblicato in Anno
New insights into the Bortezomib‐induced cytotoxic and resistance mechanisms in a primary effusion lymphoma mouse model HEMATOLOGICAL ONCOLOGY 2024
EZH2 Inhibition by DS3201 triggers the kaposi’s sarcoma-associated herpesvirus lytic cycle and potentiates the effects induced by SAHA in primary effusion lymphoma cells VIRUSES 2024
EBV infection alters DNA methylation in primary human colon cells: A path to inflammation and carcinogenesis? BIOCHIMICA ET BIOPHYSICA ACTA. GENE REGULATORY MECHANISMS 2024
Different outcome of targeting ERN1/IRE1 alpha and EIF2AK3/PERK in NSG mice engrafted with primary effusion lymphoma BRITISH JOURNAL OF HAEMATOLOGY 2023
The inhibition of IRE1alpha/XBP1 axis prevents EBV-driven lymphomagenesis in NSG mice MICROBIOLOGY SPECTRUM 2023
HSP110 Inhibition in Primary Effusion Lymphoma Cells: One Molecule, Many Pro-Survival Targets CANCERS 2023
NFE2L2 and STAT3 Converge on Common Targets to Promote Survival of Primary Lymphoma Cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
HSPs/STAT3 Interplay Sustains DDR and Promotes Cytokine Release by Primary Effusion Lymphoma Cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
NRF2 and STAT3: friends or foes in carcinogenesis? DISCOVER ONCOLOGY 2023
EBV infection of primary colonic epithelial cells causes inflammation, DDR and autophagy dysregulation, effects that may predispose to IBD and carcinogenesis VIRUS RESEARCH 2023
Zinc Supplementation Enhances the Pro-Death Function of UPR in Lymphoma Cells Exposed to Radiation BIOLOGY 2022
3,4-Dihydroxyphenylethanol (DPE or Hydroxytyrosol) Counteracts ERK1/2 and mTOR Activation, Pro-Inflammatory Cytokine Release, Autophagy and Mitophagy Reduction Mediated by Benzo[a]pyrene in Primary Human Colonic Epithelial Cells PHARMACEUTICS 2022
p62/SQSTM1 promotes mitophagy and activates the NRF2-mediated antioxidant and anti-inflammatory response restraining EBV-driven B lymphocyte proliferation CARCINOGENESIS 2022
Concomitant Inhibition of IRE1α/XBP1 Axis of UPR and PARP: A Promising Therapeutic Approach against c-Myc and Gammaherpesvirus-Driven B-Cell Lymphomas INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Mechanisms of Sensitivity and Resistance of Primary Effusion Lymphoma to Dimethyl Fumarate (DMF) INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Ire1 alpha/xbp1 axis sustains primary effusion lymphoma cell survival by promoting cytokine release and stat3 activation BIOMEDICINES 2021
Lovastatin reduces PEL cell survival by phosphorylating ERK1/2 that blocks the autophagic flux and engages a cross-talk with p53 to activate p21 IUBMB LIFE 2021
Give me a kiss! An integrative rehabilitative training program with motor imagery and mirror therapy for recovery of facial palsy EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE 2020
KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression BRITISH JOURNAL OF CANCER 2020
KSHV dysregulates bulk macroautophagy, mitophagy and UPR to promote endothelial to mesenchymal transition and CCL2 release, key events in viral-driven sarcomagenesis INTERNATIONAL JOURNAL OF CANCER 2020

ERC

  • LS4_12
  • LS6_5

Interessi di ricerca

Herpesvirus e cancro: ruolo dell'autofagia,  dello stress del reticolo (ER) e UPR (unfolded protein response) nelle neoplasie correlate all'infezione da parte di EBV e KSHV.

Keywords

Herpesviridae Infections
Herpesvirus 4
Herpesvirus 8
macroautophagy
Autophagy/UPR
unfolded protein response (UPR)
primary effusion lymphoma

Progetti di Ricerca

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