Lucia Marcocci

Pubblicazioni

Titolo Pubblicato in Anno
The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain THE JOURNAL OF BIOLOGICAL CHEMISTRY 2024
The Mechanism of Folding of Human Frataxin in Comparison to the Yeast Homologue – Broad Energy Barriers and the General Properties of the Transition State JOURNAL OF MOLECULAR BIOLOGY 2024
Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains THE JOURNAL OF BIOLOGICAL CHEMISTRY 2023
P19-derived neuronal cells express H1, H2, and H3 histamine receptors: a biopharmaceutical approach to evaluate antihistamine agents AMINO ACIDS 2023
Biophysical Characterization of the Binding Mechanism between the MATH Domain of SPOP and Its Physiological Partners INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
An intramolecular energetic network regulates ligand recognition in a SH2 domain PROTEIN SCIENCE 2023
Characterization of the folding and binding properties of the PTB domain of FRS2 with phosphorylated and unphosphorylated ligands ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2023
Addressing the Binding Mechanism of the Meprin and TRAF-C Homology Domain of the Speckle-Type POZ Protein Using Protein Engineering INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2023
Faster and sensitive zymographic detection of oxidases generating hydrogen peroxide. The case of diamine oxidase ANALYTICAL BIOCHEMISTRY 2022
Folding and binding mechanisms of the SH2 domain from Crkl BIOMOLECULES 2022
Exploring the effect of tethered domains on the folding of Grb2 protein ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS 2022
SH2 Domains: Folding, Binding and Therapeutical Approaches INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2022
Tau protein in lung smooth muscle cells JOURNAL OF RESPIRATION 2021
Copper-containing amine oxidase purified from lathyrus sativus as a modulator of human neutrophil functions INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2020
Lathyrus sativus diamine oxidase reduces clostridium difficile toxin a-induced toxicity in caco-2 cells by rescuing rhoa-gtpase and inhibiting pp38-mapKknf-κb/hif-1α activation PHYTOTHERAPY RESEARCH 2020
Vegetal diamine oxidase alleviates histamine-induced contraction of colonic muscles SCIENTIFIC REPORTS 2020
Vasa vasorum lumen narrowing in brain vascular hyalinosis in systemic hypertension patients who died of ischemic stroke INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 2020
Type E botulinum neurotoxin-producing clostridium butyricum strains are aerotolerant during vegetative growth MSYSTEMS 2019
Novel functions of vitamin E nicotinate Vitamin E: Chemistry and Nutritional Benefits 2019
Metabolomics studies to assess biological functions of vitamin e nicotinate ANTIOXIDANTS 2019

ERC

  • LS1
  • LS1_2
  • LS1_4
  • LS1_9

KET

  • Life-science technologies & biotechnologies

Interessi di ricerca

Oxidative stress, cellular antioxidant defense, cell signaling.

Antioxidant properties of natural and synthetic compounds.

Role of biogenic amines and polyamines in cell growth and differentiation.

Functional role of Cu and FAD-dependent amine oxidases. 

Histaminase properties of vegetal Cu-dependent amine oxidase.

Protein binding and folding.

Keywords

Biochemistry
copper-containing amine oxidase
diamine oxidase
monoamine oxidases
biogenic amines
histamine
reactive oxygen species (ROS)
oxidative stress
Antioxidant
cell signaling
protein binding
protein folding

Progetti di Ricerca

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