Stefano Cacchione

Pubblicazioni

Titolo Pubblicato in Anno
The S-adenosylmethionine analog sinefungin inhibits the trimethylguanosine synthase TGS1 to promote telomerase activity and telomere lengthening FEBS LETTERS 2022
TGS1 mediates 2,2,7-trimethyl guanosine capping of the human telomerase RNA to direct telomerase dependent telomere maintenance NATURE COMMUNICATIONS 2022
TGS1 impacts snRNA 3′-end processing, ameliorates survival motor neuron-dependent neurological phenotypes in vivo and prevents neurodegeneration NUCLEIC ACIDS RESEARCH 2022
Effect of space flight on the behavior of human retinal pigment epithelial ARPE-19 cells and evaluation of coenzyme Q10 treatment CELLULAR AND MOLECULAR LIFE SCIENCES 2021
Loss of Human TGS1 Hypermethylase Promotes Increased Telomerase RNA and Telomere Elongation CELL REPORTS 2020
Intimate functional interactions between TGS1 and the Smn complex revealed by an analysis of the Drosophila eye development PLOS GENETICS 2020
Silence at the End: How Drosophila Regulates Expression and Transposition of Telomeric Retroelements JOURNAL OF MOLECULAR BIOLOGY 2020
Emerging roles of telomeric chromatin alterations in cancer JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 2019
Natural aromatic compounds as scaffolds to develop selective G-quadruplex ligands. From previously reported berberine derivatives to new palmatine analogues MOLECULES 2018
The Coenzyme Q10 (CoQ10) as Countermeasure for Retinal Damage Onboard the International Space Station: the CORM Project MICROGRAVITY, SCIENCE AND TECHNOLOGY 2018
The Drosophila telomere-capping protein Verrocchio binds single-stranded DNA and protects telomeres from DNA damage response NUCLEIC ACIDS RESEARCH 2017
Telomere maintenance in the dynamic nuclear architecture Chromatin Regulation and Dynamics 2017
WDR79/TCAB1 plays a conserved role in the control of locomotion and ameliorates phenotypic defects in SMA models NEUROBIOLOGY OF DISEASE 2017
A role for Separase in telomere protection NATURE COMMUNICATIONS 2016
Perylene and coronene derivatives binding to G-rich promoter oncogene sequences efficiently reduce their expression in cancer cells BIOCHIMIE 2016
Evidence for a quadruplex structure in the polymorphic hs1.2 enhancer of the immunoglobulin heavy chain 3’ regulatory regions and its conservation in mammals BIOPOLYMERS 2016
AKTIP/Ft1, a new shelterin-interacting factor required for telomere maintenance PLOS GENETICS 2015
TRF1 and TRF2 binding to telomeres is modulated by nucleosomal organization NUCLEIC ACIDS RESEARCH 2015

Progetti di Ricerca

Laboratori di ricerca

CU026 p1 13 Manipolazione cellule animali e vegetali - analisi quantitativa polimeri biologici
CU026 p1 15 Conservazione materiale biologico a temperature controllate; analisi polimeri biologici
CU026 p1 218 Lab Didattica
CU026 p1 9 Epigenetica molecolare

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