Ricerc@Sapienza

The research group is focused on establishing advanced culture systems, including organoids and primary cell cultures, to better understand host–microorganism interactions. By recreating key features of human tissues in vitro, these models allow the team to explore infection dynamics, immune responses, and the mechanisms that drive disease progression in a controlled and physiologically relevant environment. The research groupls works closely with clinical partners to develop preclinical models that can support translational research and contribute to improved patient care.

I progetti di ricerca si concentrano sulle interazioni molecolari tra le zanzare del genere Aedes ed Anopheles, i patogeni trasmessi, e l'uomo.

Our research group focuses on understanding the molecular interactions between bacteria and the human host, with particular attention to clinically relevant Gram-negative pathogens. We use state-of-the-art cellular models, including advanced 3D cultures and organoids that faithfully reproduce human tissue structure and function. Through these innovative systems, we explore bacterial virulence mechanisms, host immune responses, and the dynamics of infection in a physiologically relevant context.

Ricerca e caratterizzazione di MCPyV e dell'espressione dei miRNA e del DDR nei tumori MCC, potenziali biomarkers per la diagnosi, la progressione, la prognosi, e potenziali bersagli terapeutici dei MCC.

Studio della capacità replicativa di MCPyV in varie linee cellulari.

The research group works in the field of clinical microbiology, with a focus on the phenotypic and genetic aspects of bacterial virulence and biofilm-formation in bacterial human pathogens and their role in infection pathogenesis and host–microbe interactions.