Ricerc@Sapienza

Multidimensional sensors represent an increasingly popular, yet challenging data source in modern statistics. Using tools from the emerging branch of Topological Data Analysis (TDA), we address two issues frequently encountered when analysing sensor data, namely their (often) high dimension and their sensibility to the reference system. We show how topological invariants provide a tool for detecting change--points which is robust with respect to both the time resolution we consider and the sensor placement.

: The early identification of pathogenic mechanisms is essential to predict the incidence and progression of cardiomyopathies and to plan appropriate preventive interventions. Noninvasive cardiac imaging such as cardiac computed tomography, cardiac magnetic resonance, and nuclear imaging plays an important role in diagnosis and management of cardiomyopathies and provides useful prognostic information.Most molecular factors exert their functions by interacting with other cellular components, thus many diseases reflect perturbations of intracellular networks.

Background/Aim: To evaluate the research trends in coronavirus disease (COVID-19). Materials and Methods: A bibliometric analysis was performed using a machine learning bibliometric methodology. Information regarding publication outputs, countries, institutions, journals, keywords, funding and citation counts was retrieved from Scopus database. Results: A total of 1883 eligible papers were returned. An exponential increase in the COVID-19 publications occurred in the last months.

Frataxin (FXN) is a highly conserved protein found in prokaryotes and eukaryotes that is required for efficient regulation of cellular iron homeostasis. Experimental evidence associates amino acid substitutions of the FXN to Friedreich Ataxia, a neurodegenerative disorder. Recently, new thermodynamic experiments have been performed to study the impact of somatic variations identified in cancer tissues on protein stability.

Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images
of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumorinfiltrating lymphocytes (TILs) based on H&E images from 13 TCGA tumor types. These TIL
maps are derived through computational staining using a convolutional neural network trained to
classify patches of images. Affinity propagation revealed local spatial structure in TIL patterns and

Precision oncology uses genomic evidence to match patients with treatment but often fails to
identify all patients who may respond. The transcriptome of these “hidden responders” may reveal
responsive molecular states. We describe and evaluate a machine-learning approach to classify
aberrant pathway activity in tumors, which may aid in hidden responder identification. The
algorithm integrates RNA-seq, copy number, and mutations from 33 different cancer types across
The Cancer Genome Atlas (TCGA) PanCanAtlas project to predict aberrant molecular states in

Recently, a daily routine for associative neural networks has been proposed: the network Hebbian-learns during the awake state (thus behaving as a standard Hopfield model), then, during its sleep state, it consolidates pure patterns and removes spurious ones, optimizing information storage: this forces the synaptic matrix to collapse to the projector one (ultimately approaching the Kanter-Sompolinsky model), allowing for the maximal critical capacity (for symmetric interactions).

The aim of this special issue is to provide a picture of the state-of-the-art and open challenges in machine learning from a statistical physics perspective, mainly that of disordered systems.

In this paper we develop statistical algorithms to infer possible cardiac pathologies, based on data collected from 24 h Holter recording over a sample of 2829 labelled patients; labels highlight whether a patient is suffering from cardiac pathologies. In the first part of the work we analyze statistically the heart-beat series associated to each patient and we work them out to get a coarse-grained description of heart variability in terms of 49 markers well established in the reference community.

We consider a three-layer Sejnowski machine and show that features learnt via contrastive divergence have a dual representation as patterns in a dense associative memory of order P = 4. The latter is known to be able to Hebbian store an amount of patterns scaling as NP -1, where N denotes the number of constituting binary neurons interacting P wisely.