Clemens Zwergel | Ricerc@Sapienza

Publications

Title	Published on	Year
Procognitive Potential of Neuroprotective Triazine 5-HT6 Receptor Antagonists Tested on Chronic Activity In Vivo in Rats: Computer-Aided Insight into the Role of Chalcogen-Differences on the Pharmacological Profile	ACS CHEMICAL NEUROSCIENCE	2025
A Xanthine Derivative With Novel Heat Shock Protein 90-Alpha Inhibitory and Senolytic Properties	AGING CELL	2025
HDAC1/2 control mesothelium/ovarian cancer adhesive interactions impacting on Talin-1-α5β1-integrin-mediated actin cytoskeleton and extracellular matrix protein remodeling	JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH	2024
First-in-Class Selenium-Containing Potent Serotonin Receptor 5-HT6 Agents with a Beneficial Neuroprotective Profile against Alzheimer's Disease	JOURNAL OF MEDICINAL CHEMISTRY	2024
SIRT3 Activation a Promise in Drug Development? New Insights into SIRT3 Biology and Its Implications on the Drug Discovery Process	JOURNAL OF MEDICINAL CHEMISTRY	2024
Mechanisms of mesothelial cell response to viral infections: HDAC1-3 inhibition blocks poly(I:C)-induced type I interferon response and modulates the mesenchymal/inflammatory phenotype	FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY	2024
Heterocycles-Containing HDAC Inhibitors Active in Cancer: An Overview of the Last Fifteen Years	CHEMMEDCHEM	2024
Selenium-containing compounds: a new hope for innovative treatments in Alzheimer’s disease and Parkinson’s disease	DRUG DISCOVERY TODAY	2024
Unlocking the potential of higher-molecular-weight 5-HT7R ligands: Synthesis, affinity, and ADMET examination	BIOORGANIC CHEMISTRY	2024
HDAC3 genetic and pharmacologic inhibition radiosensitizes fusion positive rhabdomyosarcoma by promoting DNA double-strand breaks	CELL DEATH DISCOVERY	2024
GreenMedChem- the challenge in the next decade toward eco-friendly compounds and processes in drug design	GREEN CHEMISTRY	2023
Novel 1,4-Dihydropyridines as Specific Binders and Activators of SIRT3 Impair Cell Viability and Clonogenicity and Downregulate Hypoxia-Induced Targets in Cancer Cells	JOURNAL OF MEDICINAL CHEMISTRY	2023
Histone deacetylase 10: A polyamine deacetylase from the crystal structure to the first inhibitors	CURRENT OPINION IN STRUCTURAL BIOLOGY	2023
Editorial: Frontiers in Chemistry: rising stars 2022	FRONTIERS IN CHEMISTRY	2023
HDAC1-3 inhibition increases SARS-CoV-2 replication and productive infection in lung mesothelial and epithelial cells	FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY	2023
Inhibition of PKCθ Improves Dystrophic Heart Phenotype and Function in a Novel Model of DMD Cardiomyopathy	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2022
Heterocycle-containing tranylcypromine derivatives endowed with high anti-LSD1 activity	JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY	2022
Effects of Structurally Different HDAC Inhibitors against Trypanosoma cruzi, Leishmania, and Schistosoma mansoni	ACS INFECTIOUS DISEASES	2022
Editorial: Multi-target directed ligands for the treatment of cancer	FRONTIERS IN ONCOLOGY	2022
Seleno-vs. thioether triazine derivatives in search for new anticancer agents overcoming multidrug resistance in lymphoma	EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY	2022

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ERC

LS1_13

KET

Life-science technologies & biotechnologies

Interessi di ricerca

Keywords

medicinal chemistry

Progetti di Ricerca

Discovery of new quinoline-based antimalaria agents with nanomolar potency towards multi-drug-resistant forms