Maria Elena Miranda Banos | Ricerc@Sapienza

Publications

Title	Published on	Year
An Inducible Neural Stem Progenitor Cell Model for Testing Therapeutic Interventions Against Neurodegeneration FENIB	DRUG DEVELOPMENT RESEARCH	2025
Glucocorticoids rescue cell surface trafficking of R451C Neuroligin3 and enhance synapse formation	TRAFFIC	2024
Probing of the reactive center loop region of alpha-1-antitrypsin by mutagenesis predicts new type-2 dysfunctional variants	CELLULAR AND MOLECULAR LIFE SCIENCES	2024
Role of mitochondria‐endoplasmic reticulum contacts in neurodegenerative, neurodevelopmental and neuropsychiatric conditions	EUROPEAN JOURNAL OF NEUROSCIENCE	2024
Thymol-functionalized hyaluronic acid as promising preservative biomaterial for the Inhibition of Candida albicans biofilm formation	ACS MACRO LETTERS	2023
Targeting the Antifungal Activity of Carbon Dots against Candida albicans Biofilm Formation by Tailoring Their Surface Functional Groups	CHEMISTRY-A EUROPEAN JOURNAL	2023
Novel Insights into the Link Between Myeloperoxidase Modified LDL, LOX-1, and Neuroserpin in Stroke	REVIEWS IN CARDIOVASCULAR MEDICINE	2023
Targeting the Antifungal Activity of Carbon Dots against Candida albicans Biofilm Formation by Tailoring Their Surface Functional Groups	CHEMISTRY-A EUROPEAN JOURNAL	2023
Thymol-Functionalized Hyaluronic Acid as Promising Preservative Biomaterial for the Inhibition of Candida albicans Biofilm Formation	ACS MACRO LETTERS	2023
Polymerogenic neuroserpin causes mitochondrial alterations and activates NFκB but not the UPR in a neuronal model of neurodegeneration FENIB	CELLULAR AND MOLECULAR LIFE SCIENCES	2022
Elucidating the pathological mechanisms of neurodegeneration in the lethal serpinopathy FENIB	NEURAL REGENERATION RESEARCH	2022
Serpin neuropathology in the P497S UBQLN2 mouse model of ALS/FTD	BRAIN PATHOLOGY	2021
The Importance of N186 in the Alpha-1-Antitrypsin Shutter Region Is Revealed by the Novel Bologna Deficiency Variant	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2021
G392E neuroserpin causing the dementia FENIB is secreted from cells but is not synaptotoxic	SCIENTIFIC REPORTS	2021
Neuroserpin Inclusion Bodies in a FENIB Yeast Model	MICROORGANISMS	2021
Neuroserpin: structure, function, physiology and pathology	CELLULAR AND MOLECULAR LIFE SCIENCES	2021
Association between circulating alpha-1 antitrypsin polymers and lung and liver disease	RESPIRATORY RESEARCH	2021
Glycosylation tunes neuroserpin physiological and pathological properties	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2020
Embelin as lead compound for new neuroserpin polymerization inhibitors	LIFE	2020
The alpha-1 antitrypsin polymer load correlates with hepatocyte senescence, fibrosis stage and liver-related mortality	CHRONIC OBSTRUCTIVE PULMONARY DISEASES	2020

ERC

LS1_4
LS3_6
LS5_11

Interessi di ricerca

Keywords

Neurodegeneration

Endoplasmic reticulum

Alpha 1 antitrypsin

Neuronal death

Familial encephalopathy with neuroserpin inclusion bodies

Neuroserpin

Progetti di Ricerca

An inducible neuronal model to uncover new toxicity pathways in the neurodegenerative dementia FENIB
Analysis of cytoskeletal alterations due to mutant neuroserpin in a neuronal model of the neurodegenerative dementia FENIB
Characterisation of oxidative stress and mitochondrial dysfunction due to neuroserpin polymers in the dementia FENIB
Mitochondrial dysfunction and interaction with the endoplasmic reticulum in a neuronal model of the dementia FENIB
Mechanisms of cellular toxicity activated by neuroserpin polymers in a neuronal model of the neurodegenerative dementia FENIB

Laboratori di ricerca

CU026 p2 222A Biologia Cellulare e delle Serpinopatie