Maria Elena Miranda Banos | Ricerc@Sapienza

Publications

Title	Published on	Year
Intrahepatic heteropolymerization of M and Z alpha-1-antitrypsin	JCI INSIGHT	2020
The structural basis for Z α1-antitrypsin polymerization in the liver	SCIENCE ADVANCES	2020
The molecular species responsible for α1-antitrypsin deficiency are suppressed by a small molecule chaperone	THE FEBS JOURNAL	2020
Yeast response to the expression of human proteins involved in proteinopathies	7th conference of Physiology of yeast and filamentous fungi	2019
UPR activation specifically modulates glutamate neurotransmission in the cerebellum of a mouse model of autism	NEUROBIOLOGY OF DISEASE	2018
α1-Antitrypsin Polymerizes in Alveolar Macrophages of Smokers With and Without α1-Antitrypsin Deficiency	CHEST	2018
Cellular models for the serpinopathies	Methods in Molecular Biology	2018
Development of a yeast model to investigate the molecular aspects involved in the neurodegenerative disease FENIB	From Stress Response to Tissue Development and Regeneration Pavia, Italy ¿ 28-29 September 2018	2018
Yeast as a tool to unveil the cellular and molecular mechanisms underlying neurodegeneration in FENIB disease	13th International Meeting on Yeast Apoptosis	2018
Neuroserpin polymers cause oxidative stress in a neuronal model of the dementia FENIB	NEUROBIOLOGY OF DISEASE	2017
The pathological Trento variant of alpha-1-antitrypsin (E75V) shows nonclassical behaviour during polymerization	THE FEBS JOURNAL	2017
Polymer toxicity in neurodegeneration FENIB	ONCOTARGET	2017
Polymers of Z α1-antitrypsin are secreted in cell models of disease	EUROPEAN RESPIRATORY JOURNAL	2016
Embelin binds to human neuroserpin and impairs its polymerisation	SCIENTIFIC REPORTS	2016
An antibody that prevents serpin polymerisation acts by inducing a novel allosteric behavior	BIOCHEMICAL JOURNAL	2016
Characterising the association of latency with alpha1 antitrypsin polymerisation using a novel monoclonal antibody	THE INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY	2015
A single-chain variable fragment intrabody prevents intracellular polymerisation of Z alpha1-antitrypsin while allowing its antiproteinase activity	THE FASEB JOURNAL	2015
An antibody raised against a pathogenic serpin variant induces mutant-like behaviour in the wild-type protein	BIOCHEMICAL JOURNAL	2015
Interactions between N-linked glycosylation and polymerisation of neuroserpin within the endoplasmic reticulum	THE FEBS JOURNAL	2015
Physiological modulation of BiP activity by trans-protomer engagement of the interdomain linker	ELIFE	2015

ERC

LS1_4
LS3_6
LS5_11

Interessi di ricerca

Keywords

Neurodegeneration

Endoplasmic reticulum

Alpha 1 antitrypsin

Neuronal death

Familial encephalopathy with neuroserpin inclusion bodies

Neuroserpin

Progetti di Ricerca

An inducible neuronal model to uncover new toxicity pathways in the neurodegenerative dementia FENIB
Analysis of cytoskeletal alterations due to mutant neuroserpin in a neuronal model of the neurodegenerative dementia FENIB
Characterisation of oxidative stress and mitochondrial dysfunction due to neuroserpin polymers in the dementia FENIB
Mitochondrial dysfunction and interaction with the endoplasmic reticulum in a neuronal model of the dementia FENIB
Mechanisms of cellular toxicity activated by neuroserpin polymers in a neuronal model of the neurodegenerative dementia FENIB