Valeria Pennacchietti | Ricerc@Sapienza

Publications

Title	Published on	Year
Unveiling an unexpected redox regulation of the folding, function and inhibition in the phosphotyrosine binding domain of FRS2	INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES	2025
Topological determinants in protein folding dynamics: a comparative analysis of metamorphic proteins	BIOLOGY DIRECT	2025
A single buried cysteine acts as a hydrophobic stabilizer of a folding intermediate and transition state in the MATH domain of SPOP	PROTEIN SCIENCE	2025
Allosteric modulation of Grb2 drives ligand-dependent signal responses	BIOLOGY DIRECT	2025
Exploring the short linear motif-mediated protein-protein interactions of CrkL through ProP-PD	BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS	2024
The binding selectivity of the C-terminal SH3 domain of Grb2, but not its folding pathway, is dictated by its contiguous SH2 domain	THE JOURNAL OF BIOLOGICAL CHEMISTRY	2024
The Mechanism of Folding of Human Frataxin in Comparison to the Yeast Homologue – Broad Energy Barriers and the General Properties of the Transition State	JOURNAL OF MOLECULAR BIOLOGY	2024
PDZ2-conjugated-PLGA nanoparticles are tiny heroes in the battle against SARS-CoV-2	SCIENTIFIC REPORTS	2024
Folding and binding kinetics of the tandem of SH2 domains from SHP2	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2024
A PDZ tandem repeat folds and unfolds via different pathways	PROTEIN SCIENCE	2024
Understanding the molecular basis of folding cooperativity through a comparative analysis of a multidomain protein and its isolated domains	THE JOURNAL OF BIOLOGICAL CHEMISTRY	2023
Different electrostatic forces drive the binding kinetics of SARS-CoV, SARS-CoV-2 and MERS-CoV Envelope proteins with the PDZ2 domain of ZO1	SCIENTIFIC REPORTS	2023
Monomeric and dimeric states of human ZO1-PDZ2 are functional partners of the SARS-CoV-2 E protein	COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL	2023
Biophysical Characterization of the Binding Mechanism between the MATH Domain of SPOP and Its Physiological Partners	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2023
An intramolecular energetic network regulates ligand recognition in a SH2 domain	PROTEIN SCIENCE	2023
Characterization of the folding and binding properties of the PTB domain of FRS2 with phosphorylated and unphosphorylated ligands	ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS	2023
Addressing the Binding Mechanism of the Meprin and TRAF-C Homology Domain of the Speckle-Type POZ Protein Using Protein Engineering	INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES	2023
On the effects of disordered tails, supertertiary structure and quinary interactions on the folding and function of protein domains	BIOMOLECULES	2022
Characterization of early and late transition states of the folding pathway of a SH2 domain	PROTEIN SCIENCE	2022
Folding and binding mechanisms of the SH2 domain from Crkl	BIOMOLECULES	2022