Ricerc@Sapienza

1. Analysis of the role of Notch pathway in solid tumors: implications in cancer development and progression.

2. Analysis of molecular and cellular mechanisms involved in leukemia development and progression.

3. Generation, phenotypic and functional characterization of murine of neoplastic diseases (Notch3 tg mice and Notch3 tg+/pTalpha-/-, Notch3 tg+/PKCtheta-/- Notch3 tg+/Pin1-/- double mutant mice).

4. Development of in vitro thymocytes differentiation models.

5. Analysis of cellular and molecular mechanisms involved in T cell and thymocytes differentiation.