Saula Checquolo

Publications

Title Published on Year
PLK1 targets NOTCH1 during DNA damage and mitotic progression THE JOURNAL OF BIOLOGICAL CHEMISTRY 2019
Notch3 contributes to T-cell leukemia growth via regulation of the unfolding protein response The Biennial Congress of the Italian Association of cell biology and differentiation 2019
Notch signaling as a therapeutic target for acute lymphoblastic leukemia EXPERT OPINION ON THERAPEUTIC TARGETS 2018
NOTCH3 inactivation increases Triple Negative Breast Cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest. Atti del ABCD - PPh.D. meeting 2018
NOTCH3 inactivation increases triple negative breast cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest. ONCOGENESIS 2018
Targeting the ER/UPR signalling in Notch3-overexpressing T-cell acute lymphoblastic leukemia. Atti del ABCD - Ph.D. meeting 2018
The Notch3 receptor and its intracellular signaling-dependent oncogenic mechanisms Molecular Mechanisms of Notch Signaling 2018
Notch3 and CXCR4 cross-signaling sustains acute T-cell leukemia progression ESMO OPEN 2018
Potential targeted therapy for T-cell acute lymphoblastic leukemia: perturbing ER/UPR signaling via Notch3 down-regulation Cell communication and signaling: how to turn bad language into positive one 2018
Maml1 acts cooperatively with Gli proteins to regulate Sonic hedgheog signaling pathway CELL DEATH & DISEASE 2017
Cytotoxic activity of Juglone against Notch3-overexpressing T-cell acute lymphoblastic leukemia: targeting the ER/UPR signaling Notch meeting X 2017
Role of Notch3 in sustaining UPR signaling in Notch3-overexpressing T-cell acute lymphoblastic leukemia. Atti del SIPMeT "Young Scientist Meeting" 2017
Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression ONCOGENE 2016
RET mutation and increased angiogenesis in medullary thyroid carcinomas ENDOCRINE-RELATED CANCER 2016
Notch3 sustains CXCR4 expression in acute T cell lymphoblastic leukemia progression EUROPEAN JOURNAL OF CANCER 2016
The deregulated expression of miR-125b in acute myeloid leukemia is dependent on the transcription factor C/EBPalpha LEUKEMIA 2015

Interessi di ricerca

1. Analysis of the role of Notch pathway in solid tumors: implications in cancer development and progression.

2. Analysis of molecular and cellular mechanisms involved in leukemia development and progression.

3. Generation, phenotypic and functional characterization of murine of neoplastic diseases (Notch3 tg mice and Notch3 tg+/pTalpha-/-, Notch3 tg+/PKCtheta-/- Notch3 tg+/Pin1-/- double mutant mice).

4. Development of in vitro thymocytes differentiation models.

5. Analysis of cellular and molecular mechanisms involved in T cell and thymocytes differentiation.

Progetti di Ricerca

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