Marialaura Petroni | Ricerc@Sapienza

Publications

Title	Published on	Year
The Multiple Faces of the MRN Complex: Roles in Medulloblastoma and Beyond	CANCERS	2023
SALL4 is a CRL3^REN/KCTD11 substrate that drives Sonic Hedgehog-dependent medulloblastoma	CELL DEATH AND DIFFERENTIATION	2023
A gene dosage‐dependent effect unveils NBS1 as both a haploinsufficient tumour suppressor and an essential gene for SHH‐medulloblastoma	NEUROPATHOLOGY & APPLIED NEUROBIOLOGY	2022
Specific Protein 1 and p53 Interplay Modulates the Expression of the KCTD-Containing Cullin3 Adaptor Suppressor of Hedgehog 2	FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY	2021
A combination of PARP and CHK1 inhibitors efficiently antagonizes MYCN-driven tumors	ONCOGENE	2021
Phenformin inhibits hedgehog-dependent tumor growth through a complex i-independent redox/corepressor module	CELL REPORTS	2020
The rna-binding ubiquitin ligase mex3a affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of rig-i	CANCERS	2020
Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer	FRONTIERS IN ONCOLOGY	2020
Blockade of EIF5A hypusination limits colorectal cancer growth by inhibiting MYC elongation	CELL DEATH & DISEASE	2020
A novel BRCA2 splice variant identified in a young woman	MOLECULAR GENETICS & GENOMIC MEDICINE	2020
Mitogen-activated kinase kinase kinase 1 inhibits hedgehog signaling and medulloblastoma growth through GLI1 phosphorylation	INTERNATIONAL JOURNAL OF ONCOLOGY	2019
A simplified genomic profiling approach predicts outcome in metastatic colorectal cancer	CANCERS	2019
Next-generation sequencing of BRCA1 and BRCA2 genes for rapid detection of germline mutations in hereditary breast/ovarian cancer	PEERJ	2019
SMO-M2 mutation does not support cell-autonomous Hedgehog activity in cerebellar granule cell precursors	SCIENTIFIC REPORTS	2019
Identification of novel BRCA1 large genomic rearrangements by a computational algorithm of amplicon-based Next-Generation Sequencing data	PEERJ	2019
Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis	NATURE COMMUNICATIONS	2018
Effective treatment of a platinum-resistant cutaneous squamous cell carcinoma case by EGFR pathway inhibition	MOLECULAR AND CLINICAL ONCOLOGY	2018
MRE11 inhibition highlights a replication stress-dependent vulnerability of MYCN-driven tumors	CELL DEATH & DISEASE	2018
Selective targeting of HDAC1/2 elicits anticancer effects through Gli1 acetylation in preclinical models of SHH Medulloblastoma.	SCIENTIFIC REPORTS	2017
PARP inhibitors enhance replication stress and cause mitotic catastrophe in MYCN-dependent neuroblastoma	ONCOGENE	2017

ERC

LS1
LS1_9
LS3_6
LS4_12
LS5_3
LS5_11

KET

Life-science technologies & biotechnologies

Interessi di ricerca

Keywords

Medulloblastoma

DNA damage response

primary cilium

Neuroblastoma

Progetti di Ricerca

Exploring a new function of the Nijmegen breakage syndrome (NBS1) gene in Primary Cilia regulation.