C-di-GMP

Nucleotides and nanoRNA homeostasis characterization and targeting.

Nucleotides and nanoRNA homeostasis characterization and targeting.

Phosphodiesterases (PDEs) are relevant for biological processes such as RNA homeostasis (exoribonucleases) and second messengers-mediated signal transduction, including mono- and dinucleotides; targeting of selected PDEs in different pathological processes may offer therapeutic strategies.

Nutrient sensing and redox transducers in bacterial biofilm.

Nutrient sensing and redox transducers in bacterial biofilm.

Bacteria can behave as multicellular community named biofilm, which confer them protection against host defense and hostile environments. The switch between planktonic to biofilm lifestyle is controlled by the variation of the intracellular levels of the second messenger bis-(3′,5′)-cyclic-dimeric-guanosine (c-di-GMP).

Insights into the GTP-dependent allosteric control of c-di-GMP hydrolysis from the crystal structure of PA0575 protein from Pseudomonas aeruginosa

Bis-(3'-5')-cyclic diguanylic acid (c-di-GMP) belongs to the class of cyclic dinucleotides, key carriers of cellular information in prokaryotic and eukaryotic signal transduction pathways. In bacteria, the intracellular levels of c-di-GMP and their complex physiological outputs are dynamically regulated by environmental and internal stimuli, which control the antagonistic activities of diguanylate cyclases (DGCs) and c-di-GMP specific phosphodiesterases (PDEs). Allostery is one of the major modulators of the c-di-GMP-dependent response.

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