diabetic painful polyneuropathy

Laboratorio di Malattie del Sistema Nervoso Periferico e Neurofisiopatologia del Dolore - Pain Lab

The Pain Lab brings together neurophysiologists, neurologists, and technicians to investigate the mechanisms underlying chronic pain, with a particular emphasis on painful neuropathies. Using advanced neurophysiological testing and immunofluorescence microscopy, the lab aims to identify objective biomarkers and mechanistic pathways linking peripheral neural abnormalities to chronic pain.

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High-Dose intravenous immunoglobulin is effective in painful diabetic polyneuropathy resistant to conventional treatments. Results of a double-blind, randomized, placebo-controlled, multicenter trial

Objectives: The efficacy and safety of high-dose intravenous immunoglobulin (IVIG) in treatment-resistant diabetic painful polyneuropathy (DPN) were assessed. Design: This was a randomized, double-blind, placebo-controlled, multicenter trial (EudraCT 2010-023883-42). Setting: This trial was conducted at eight sites in Italy with a neurology specialist level of care.