Editorial: Myokines, Adipokines, Cytokines in Muscle Pathophysiology
Individual striated muscle fibers communicate in both a paracrine and endocrine fashion and are
also involved in the crosstalk with other tissues and organs such as the adipose tissue, immune
system, liver, pancreas, bones, and brain (Delezie andHandschin, 2018). The striatedmuscle, which
accounts for 40% of bodymass, presents high biosynthetic activity, and extensive vascularization,
features that endorse current thinking that muscle is the largest endocrine system of the body