Ricerc@Sapienza

The role of enhancers, a key class of non-coding regulatory DNA elements, in cancer development has increasingly been appreciated. Here, we present the detection and characterization of a large number of expressed enhancers in a genome-wide analysis of 8928 tumor samples across 33 cancer types using TCGA RNA-seq data. Compared with matched normal tissues, global enhancer activation was observed in most cancers.

Metabolic reprogramming provides critical information for clinical oncology. Using molecular
data of 9,125 patient samples from The Cancer Genome Atlas, we identified tumor subtypes in 33
cancer types based on mRNA expression patterns of seven major metabolic processes and assessed
their clinical relevance. Our metabolic expression subtypes correlated extensively with clinical
outcome: subtypes with upregulated carbohydrate, nucleotide, and vitamin/cofactor metabolism

In primary biliary cholangitis (PBC), macrophages are involved in liver inflammation and fibrosis. The macrophage activation markers, soluble (s)CD163 and mannose receptor (sMR) are associated with liver disease severity and prognosis in other chronic liver diseases. We aimed to investigate sCD163 and sMR in patients with PBC.