Ricerc@Sapienza

Background: Oropharyngeal mucositis occurs in virtually all patients with head and neck cancer receiving radiochemotherapy. The manipulation of the oral cavity microbiota represents an intriguing and challenging target. Patients and Methods: A total of 75 patients were enrolled to receive Lactobacillus brevis CD2 lozenges or oral care regimen with sodium bicarbonate mouthwashes. The primary endpoint was the incidence of grade 3 or 4 oropharyngeal mucositis during radiotherapy treatment.

Background and Objectives: Gastric cancers are usually characterized using Lauren's classification into intestinal and diffuse types. We previously documented the down-modulation of miR31, miR148a, miR204, and miR375 in gastric cancers. We aimed this manuscript to investigate these miRs with the end-points of diagnosis, Lauren's classification and prognosis. Methods: A total of 117 resected non-cardial adenocarcinomas were evaluated for miRs' expressions. The performance of miRs’ expressions for cancer diagnosis was tested using ROC curves.

Purpose The purpose was to assess image quality of portal-venous phase dual-energy computed tomography (DECT) for liver lesions. Methods We performed 120-kVp-equivalent linear-blended (LB) and monoenergetic reconstructions from 40 to 190 keV by standard (VMI) and advanced virtual monoenergetic (VMI+) methods. Diagnostic performance, and quantitative and qualitative image analyses were assessed and compared. Results Liver contrast to noise ratio peaked at 40 keV_VMI+, while image quality and reader preference peaked at 50 keV_VMI+.

editorial no abstract available

Objectives/Hypothesis: During intraoperative neural monitoring (IONM) in thyroid and parathyroid surgery, endotracheal
(ET) tube migration can result in a decrease in vocalis electromyographic (EMG) amplitude without a concordant latency
elevation during stimulation of the recurrent laryngeal nerve (RLN).
Study Design: Retrospective review.
Methods: Data were reviewed retrospectively for thyroid and parathyroid surgery patients with IONM of the laryngeal

Absorption, the ability to highly focus attention, as well as openness to self-altering experiences, is an important psychological construct, closely related to deep-meditation states and other altered states of consciousness. Yet, little is known about the electrophysiological profile of states of absorption, possibly due to the difficulty to induce this state in the lab.

In the study of the electrophysiological correlates of attention, a phasic change in alertness has been classically related to a negative frontal-central shift called Contingent Negative Variation (CNV). Studies investigating the effects of meditation on the CNV in participants reporting frequent transcendental experiences (TE) reported reduced CNV in choice reaction time task (CRT), and increased CNV in simple reaction time task (SRT), suggesting that meditation can induce a more balanced attentional state.

Epidemiological data indicate that risk behaviors are among the leading causes of adolescent morbidity and mortality worldwide. Consistent with this, laboratory-based studies of age differences in risk behavior allude to a peak in adolescence, suggesting that adolescents demonstrate a heightened propensity, or inherent inclination, to take risks. Unlike epidemiological reports, studies of risk taking propensity have been limited to Western samples, leaving questions about the extent to which heightened risk taking propensity is an inherent or culturally constructed aspect of adolescence.

Our behavior entails a flexible and context-sensitive interplay between brain areas to integrate information according to goal-directed requirements. However, the neural mechanisms governing the entrainment of functionally specialized brain areas remain poorly understood. In particular, the question arises whether observed changes in the regional activity for different cognitive conditions are explained by modifications of the inputs to the brain or its connectivity?

A fundamental question in systems neuroscience is how endogenous neuronal activity self-organizes during particular brain states. Recent neuroimaging studies have demonstrated systematic relationships between resting-state and task-induced functional connectivity (FC). In particular, continuous task studies, such as movie watching, speak to alterations in coupling among cortical regions and enhanced fluctuations in FC compared to the resting-state.