Ricerc@Sapienza

Antioxidants are helpful in prevention of several diseases related with oxidative stress including neurodegenerative disorders. In recent studies, carbazoles were given proof of promising antioxidant activities. In this article, 9-ethyl-9H-carbazole hydrazone derivatives were synthesized, characterized and their invitroantioxidant activity and possible cytotoxic effects were investigated. Furthermore, protective effect of the synthesized derivatives against amyloid β-induced damage in PC12 neuronal cells was examined by using MTT assay.

Mounting evidence from clinical and epidemiological studies suggests that lycopene, the most abundant carotenoid in tomatoes, may be beneficial in the prevention or treatment of some important diseases. Ripe tomato peels are the richest source of lycopene, but the use of conventional solvent extraction methods without pretreatment of the plant material results in very poor recovery. The reason lies in the localization of lycopene in the plant tissue and the low permeability of the latter to solvent molecules.

Marine species represent a great source of biologically active substances; Actinia equina (AE),
an Anthozoa Cnidaria belonging to the Actinidiae family, have been proposed as original food and have
already been included in several cooking recipes in local Mediterranean shores, and endowed with
excellent nutraceutical potential. The aim of this study was to investigate some unexplored features
of AE, through analytical screening and an in-vitro and in-vivo model. An in-vitro study, made on