awake passive state | Ricerc@Sapienza

Ongoing electroencephalographic activity associated with cortical arousal in trangenic pdapp mice

Background: It has been shown that theta (6-10 Hz) and delta (1-6 Hz) ongoing
electroencephalographic (EEG) rhythms revealed variations in the cortical arousal in C57 Wild Type
(WT) mice during cage exploration (active condition) compared to awake quiet behavior (passive
condition; IMI PharmaCog project, www.pharmacog.eu).
Objective: The objective was to test if these EEG rhythms might be abnormal in old PDAPP mice
modeling Alzheimer’s disease (AD) with a hAPP Indiana V717F mutation (They show abnormal neural

On-going electroencephalographic rhythms related to cortical arousal in wild-type mice: the effect of aging

Resting state electroencephalographic (EEG) rhythms reflect the fluctuation of cortical arousal and vigilance in a typical clinical setting, namely the EEG recording for few minutes with eyes closed (i.e., passive condition) and eyes open (i.e., active condition). Can this procedure be back-translated to C57 (wild type) mice for aging studies? On-going EEG rhythms were recorded from a frontoparietal bipolar channel in 85 (19 females) C57 mice.