Ricerc@Sapienza

Background: It has been shown that theta (6-10 Hz) and delta (1-6 Hz) ongoing
electroencephalographic (EEG) rhythms revealed variations in the cortical arousal in C57 Wild Type
(WT) mice during cage exploration (active condition) compared to awake quiet behavior (passive
condition; IMI PharmaCog project, www.pharmacog.eu).
Objective: The objective was to test if these EEG rhythms might be abnormal in old PDAPP mice
modeling Alzheimer’s disease (AD) with a hAPP Indiana V717F mutation (They show abnormal neural
transmission, cognitive deficits, and brain accumulation of A?1-42).
Methods: Ongoing EEG rhythms were recorded by a frontoparietal bipolar channel in 15 PDAPP and 23
WT C57 male mice (mean age of 22.8 months ±0.4 and 0.3 standard error, respectively). EEG absolute
power (density) was calculated. Frequency and amplitude of individual delta and theta frequency (IDF
and ITF) peaks were considered during passive and active states in the wakefulness.
Results: Compared with the WT group, the PDAPP group showed higher frequency of the IDF during
the passive condition and lower frequency of the ITF during the active state. Furthermore, the WT but
not PDAPP group showed significant changes in the frontoparietal EEG power (IDF, ITF) during active
over passive state.
Conclusion: PDAPP mice were characterized by less changes in the brain arousal during an active state
as revealed by frontoparietal EEG rhythms. Future studies will have to cross-validate the present results
on large animal groups, clarify the neurophysiological underpinning of the effect, and test if the disease
modifying drugs against AD amyloidosis normalize those candiate EEG biomarkers in PDAPP mice