epigenetics

Mozzetta Lab, Laboratory of Muscle Epigenetics & Regeneration

Mozzetta Lab, Laboratory of Muscle Epigenetics & Regeneration

The Mozzetta Lab investigates the epigenetic mechanisms that regulate skeletal muscle homeostasis, regeneration, and disease. Our research focuses on how chromatin organization, nuclear architecture, and transcriptional networks control muscle stem cells and stromal progenitors, with particular attention to fibro-adipogenic progenitors (FAPs), key regulators of muscle repair and degeneration.

Extracellular vesicles/ncRNAs-mediated multicellular dynamics

Extracellular vesicles/ncRNAs-mediated multicellular dynamics

Our research projects aim at the identification of RNA-binding proteins interacting with microRNAs and responsible for their loading into small extracellular vesicles.

Clinical Biochemistry and Clinical Molecular Biology

Clinical Biochemistry and Clinical Molecular Biology

Our lab studies the epigenetic and molecular mechanisms related to cystic fibrosis, dyslipidemia, alcohol dependence, neuromuscular differentiation and neurodegeneration.For some of these pathologies,epigenetic, theratyping and gene editing therapeutic approaches are being evaluated. Diagnostic, therapeutic and health care support in the areas of Clinical Pathology,Clinical Biochemistry,Hematology and Coagulation as the central laboratory of the AOU Policlinico Umberto I is provided.

MNC - Molecular Networks in Cancer Unit

MNC - Molecular Networks in Cancer Unit

Alterations in Notch signaling play a crucial role in cancer development and progression. Depending on the cancer context, Notch signaling can act as either an oncogene or a tumor suppressor. Understanding the mechanisms underlying this dual role is essential for identifying novel molecular targets and developing innovative therapeutic strategies.

CiapponiLab

CiapponiLab

Drosophila melanogaster is a highly conserved animal system, similar with vertebrates in many basic biological, physiological, and neurological aspects. Drosophila genome is 60% homologous to that of humans, less redundant, and about 75% of the genes responsible for human diseases have homologs in flies. These features, together with a brief generation time, low maintenance costs, and the availability of powerful genetic tools, allow the fruit fly to be eligible to study complex pathways relevant in biomedical research, including cancer and neuromuscular diseases.

EPIGENETICS METABOLISM AND CANCER UNIT (EMCU)

EPIGENETICS METABOLISM AND CANCER UNIT (EMCU)

 

Lab website: https://sites.google.com/uniroma1.it/emculab-canettieri

 

 

Our laboratory is interested in understanding how epigenetic and metabolic reprogramming influence tumor behaviour and to invetigate the possibility to target these alterations for therapeutic purposes.

The current main topics of our lab are:

1) Energy and redox rewiring in Cancer

Part 1: EPIGENETICS, OXIDATIVE STATES AND DIABETES in: DIABETES: OXIDATIVE STRESS AND DIETARY ANTIOXIDANTS

Diabetes: Oxidative Stress and Dietary Antioxidants, Second Edition, builds on the success of the first edition, covering updated research on the science of oxidative stress in diabetes and the potentially therapeutic usage of natural antioxidants in the diet and food matrix. The processes within the science of oxidative stress are not described in isolation, but rather in concert with other processes, such as apoptosis, cell signaling and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this.

Recent advances in epigenetic proteolysis targeting chimeras (Epi-PROTACs)

PROteolysis TArgeting Chimeras (PROTACs) are heterobifunctional molecules that trigger the poly-ubiquitination of the protein of interest (POI) inducing its degradation via the recruitment of the ubiquitin-proteasome system, thus suppressing the POI's intracellular levels and indirectly all its functions. Recently, one of the fields where the protein knockdown induced by PROTACs has demonstrated to serve as a promising biochemical tool and to provide new opportunities for drug discovery is the epigenetics (epi-PROTACs).

Interplay between metabolites and the epigenome in regulating embryonic and adult stem cell potency and maintenance

The environment surrounding stem cells has the ability to elicit profound, heritable epigenetic changes orchestrated by multiple epigenetic mechanisms, which can be modulated by the level of specific metabolites. In this review, we highlight the significance of metabolism in regulating stem cell homeostasis, cell state, and differentiation capacity, using metabolic regulation of embryonic and adult muscle stem cells as examples, and cast light on the interaction between cellular metabolism and epigenetics.

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