homer

Homer1 scaffold proteins govern Ca2+ dynamics in normal and reactive astrocytes

In astrocytes, the intracellular calcium (Ca2+) signaling mediated by activation of metabotropic glutamate receptor 5 (mGlu5) is crucially involved in the modulation of many aspects of brain physiology, including gliotransmission. Here, we find that the mGlu5-mediated Ca2+ signaling leading to release of glutamate is governed by mGlu5 interaction with Homer1 scaffolding proteins. We show that the long splice variants Homer1b/c are expressed in astrocytic processes, where they cluster with mGlu5 at sites displaying intense local Ca2+ activity.

Euripide padre della commedia nuova? A proposito di Satiro, Vit.Eur. P.Oxy. 1167, fr. 39 col. VII e di altre testimonianze antiche

New edition with commentary of Satyrus, V.Eur. P.Oxy. 1167, fr. 39, col. VII. Satyrus does not anticipate the modern theory that Euripides' romantic tragedies are the starting point of late comic theatre and that Euripides, therefore, is the father of the New Comedy. Rather, in a speech entirely devoted to the use by both Euripides and the comic poets of real-life situations, Satyrus is just noting that Euripides dealt with everyday matters at the highest levels.

(Im)politeness in the Iliad. The pragmatics of the Homeric expression ἀγαθός περ ἐών

Every communication has a relationship aspect in addition to a content aspect: this axiom of Watzlawick's Pragmatics of Human Communication proves useful also when studying the dialogues contained in literary works. The ἀγαθός περ ἐών formula occurring five times in Homer’s Iliad has appeared difficult to interpret precisely because scholars have failed to take into account the relationship aspect of the verbal interactions described.

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