Host-Pathogen Interactions

CELL STRESS BIOLOGY

CELL STRESS BIOLOGY

Prof. Fimia carries out his research actiivity at the “Cell Stress Biology” laboratory of Department of Molecular Medicine, as well as at the Cell Biology and Electron Microscopy lab of the National Institute for Infectious Diseases (INMI) L. Spallanzani in Rome,
where the Prof. Fimia has part of his research group to carry out research activity on the basis of a formal Collaborative Agreement. 

Fungal lipids.Biosynthesis and signalling during plant-pathogen interaction

Lipids occur in fungi as major constituents of the membrane systems and minor component in the cell wall; they can store energy in the lipid bodies and, in some cases, they can act as intra-extracellular signals. Fungi contain a various set of lipids, including fatty acids, oxylipins, sphingolipids, phospholipids, glycolipids, and sterols. Current studies in lipids suggest their additional role in cell signalling; for instance, host-pathogen exchange lipid signals at the interface during their interaction.

EBV and KSHV Infection Dysregulates Autophagy to Optimize Viral Replication, Prevent Immune Recognition and Promote Tumorigenesis

Autophagy is a catabolic process strongly involved in the immune response, and its dysregulation contributes to the onset of several diseases including cancer. The human oncogenic gammaherpesviruses, EpsteinBarr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV), manipulate autophagy, either during the de novo infection or during the lytic reactivation, in naturally latently-infected lymphoma cells.

© Università degli Studi di Roma "La Sapienza" - Piazzale Aldo Moro 5, 00185 Roma