hsv-1 | Ricerc@Sapienza

Multiple Herpes simplex virus-1 (HSV-1) reactivations induce protein oxidative damage in mouse brain. Novel mechanisms for Alzheimer’s disease progression

Compelling evidence supports the role of oxidative stress in Alzheimer’s disease (AD) pathophysiology. Interestingly, Herpes simplex virus-1 (HSV-1), a neurotropic virus that establishes a lifelong latent infection in the trigeminal ganglion followed by periodic reactivations, has been reportedly linked both to AD and to oxidative stress conditions.

A polyphenol rich extract from Solanum melongena L. DR2 peel exhibits antioxidant properties and anti-herpes simplex virus type 1 activity in vitro

DR2B and DR2C extracts, obtained by ethanolic maceration of peel from commercially
and physiologically ripe aubergine berries, were studied for the antioxidative cytoprotective
properties and anti-HSV-1 activity, in line with the evidence that several antioxidants can impair
viral replication by maintaining reducing conditions in host cells. The antioxidative cytoprotective
effects against tBOOH-induced damage were assessed in Caco2 cells, while antiviral activity was