hyperglycemia-induced oxidative stress

Epigenetic alterations in aging and in endocrine and metabolic diseases

Epigenetic alterations in aging and in endocrine and metabolic diseases

Aging and endocrine-metabolic diseases are complex conditions characterized by profound epigenetic alterations that affect gene expression and cellular function. Epigenetic mechanisms, such as DNA methylation and hydroxymethylation, play a central role in the adaptation of cells to environmental and metabolic stimuli.

Hypoglycemic, antiglycation, and cytoprotective properties of a phenol-rich extract from waste peel of punica granatum L. Var. Dente di cavallo DC2

Pomegranate peel is a natural source of phenolics, claimed to possess healing properties, among which are antioxidant and antidiabetic. In the present study, an ethyl acetate extract, obtained by Soxhlet from the peel of Dente di Cavallo DC2 pomegranate (PGE) and characterized to contain 4% w/w of ellagic acid, has been evaluated for its hypoglycemic, antiglycation, and antioxidative cytoprotective properties, in order to provide possible evidence for future nutraceutical applications.

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