Ricerc@Sapienza

Increasing evidence suggests that in Amyotrophic Lateral Sclerosis (ALS) mutated RNA binding proteins acquire aberrant functions, leading to altered RNA metabolism with significant impact on encoded protein levels. Here, by taking advantage of a human induced pluripotent stem cell-based model, we aimed to gain insights on the impact of ALS mutant FUS on the motoneuron proteome.

The production of low alcohol beer (LAB) with a full and well-balanced flavour is still now a complex challenge because of the
different flavour profile they have compared to regular beers. In this study, a brown ale beer was used to obtain a low alcohol beer
by osmotic distillation in a small pilot plant. Beer-diluted carbonated solutions were used as strippers and were taken under flux
of CO2 in order to contrast loss of volatiles from beer during the process. A forced carbonation was applied on LAB to avoid the