MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity
MicroRNAs are endogenous, noncoding RNAs crucial for the post-transcriptional regulation of gene
expression. In this study, we investigated the role of miR-335-5p in spatial learning and synaptic plastic- ity.
To this end we first showed spatial learning induced down-regulation of miR-335-5p. Next we found
impairment in long-term memory and reduction in hippocampal long-term potentiation by exogenous
administration of the miRNA. These findings demonstrate that miR-335-5p is a key coordinator of the