MicroRNA-335-5p modulates spatial memory and hippocampal synaptic plasticity
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Capitano F., Camon J., Licursi V., Ferretti V., Maggi L., Scianni M., Del Vecchio G., Rinaldi A., Mannironi C., Limatola C., Presutti C., Mele A.
ISSN: 1074-7427
MicroRNAs are endogenous, noncoding RNAs crucial for the post-transcriptional regulation of gene
expression. In this study, we investigated the role of miR-335-5p in spatial learning and synaptic plastic- ity.
To this end we first showed spatial learning induced down-regulation of miR-335-5p. Next we found
impairment in long-term memory and reduction in hippocampal long-term potentiation by exogenous
administration of the miRNA. These findings demonstrate that miR-335-5p is a key coordinator of the
intracellular pathways that mediate experience-dependent changes in the brain.