patients’ derived primary cells

Organoid Lab

Organoid Lab

The research group is focused on establishing advanced culture systems, including organoids and primary cell cultures, to better understand host–microorganism interactions. By recreating key features of human tissues in vitro, these models allow the team to explore infection dynamics, immune responses, and the mechanisms that drive disease progression in a controlled and physiologically relevant environment. The research groupls works closely with clinical partners to develop preclinical models that can support translational research and contribute to improved patient care.

The miR-139-5p regulates proliferation of supratentorial paediatric low-grade gliomas by targeting the PI3K/AKT/mTORC1 signalling

Paediatric low-grade gliomas (pLGGs) are a heterogeneous group of brain tumours associated with a high overall survival: however, they are prone to recur and supratentorial lesions are difficult to resect, being associated with high percentage of disease recurrence. Our aim was to shed light on the biology of pLGGs.

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